Genetics of Immunological Diseases pp 289-294 | Cite as
Susceptibility and Resistance to Plasmacytomagenesis: Possible Role of Genes That Modify Efficiency of Chromatin Repair
Conference paper
Abstract
The responsiveness of inbred mice to microbial pathogens and tumor-inducing agents can vary with individual strains. Thus, the genotype of a given strain can determine whether the mouse will be susceptible or resistant to the development of a disease process.In many cases the phenotype is controlled by more than one gene. Identification of specific genes usually requires that two reference strains, a susceptible and resistant one, be used in the genetic analysis and the genes defined are referable to the two strains compared. The responses to pathogenic agents can be broken down into two general steps: the first (afferent pathway) governs how a specific strain of mice interacts with the pathogenic agent(chemical or microbial) and the second set of responses relates to the damage incurred and how the damaged cells cope with the agent or its effects (efferent pathway).
Keywords
Partial Resistance Current Topic Congenic Strain Pathogenic Agent Illegitimate Recombination
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