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Tracer Kinetic Modeling in Positron Computed Tomography

  • Sung-Cheng Huang
  • Richard E. Carson
  • Michael E. Phelps
Part of the Lecture Notes in Biomathematics book series (LNBM, volume 48)

Abstract

The tracer technique uses a measurable substance to trace a dynamic process, such as flow, transport, or chemical reactions. The technique is neither new nor rarely used. For example, it has been used in our daily lives to estimate intuitively the flow speed in a river by observing the drifting of floats in the river. The application of the technique to physiological systems in the 19th century by injecting dye in the circulatory system to measure cardiac output(1, 2). The success of this application has led to many biomedical tracer techniques, including the measurement of cerebral blood flow in man(3). After the development of radioisotope tracer techniques(4) and external detection capabilities, tracer techniques have become widely used in many applications(5–9). With the recent development of positron emission computed tomography, i.e., positron CT(10), tracer techniques became an essential, integral part of this new technique for measuring many physiologic or biochemical parameters in man(ll, 12). Studies dealing with the principles and treatment of tracer techniques developed in parallel and have become more rigorous (13–17).

Keywords

Operational Equation Natural Substrate Positron Emission Tomograph Tracer Technique Positron Emission Compute Tomography 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1983

Authors and Affiliations

  • Sung-Cheng Huang
    • 1
  • Richard E. Carson
    • 1
  • Michael E. Phelps
    • 1
  1. 1.UCLA Medical SchoolLos AngelesUSA

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