Abstract
We have been interested in models of adjuvant immune activation which would be capable of amplifying responsiveness both in vivo and in vitro.,and we have spent some time studying the ability of the synthetic polyribonucleotides, namely polyadenylic-polyuridylic acids, in amplifying the specific immune responsiveness of lymphocytes in vitro. We have found that the synthetic double-stranded polyribonucleotide polyadenylic-polyuridylic acid (poly AU) will enhance both the response of sensitized leukocytes to suboptimal concentrations of strong soluble antigens and the response of nonsensitized leukocytes to suboptimal concentrations of allogeneic leukocytes. Furthermore, our experience with the measles virus a poor stimulus in leukocyte cultures, indicates that poly AU may be useful in in vitro. studies designed to detect cellular immune reaction to this type of antigen preparation.
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© 1974 Springer-Verlag Berlin · Heidelberg
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Mardiney, M.R., Chess, L., Levy, C., Schmukler, M., Smith, K. (1974). Use of Double-Stranded Synthetic Polynucleotides in Amplifying Immunologically Induced Lymphocyte Proliferation. In: Mathé, G., Weiner, R. (eds) Investigation and Stimulation of Immunity in Cancer Patients. Recent Results in Cancer Research, vol 47. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-49284-6_47
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DOI: https://doi.org/10.1007/978-3-642-49284-6_47
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