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Recombinant Human Granulocyte-Macrophage Colony-Stimulating Factor in Aplastic Anemia: A Phase I/II Trial with Emphasis on Very Severe Neutropenia and Active Infection

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Cytokines in Hemopoiesis, Oncology, and AIDS II

Abstract

Acquired aplastic anemia (AA) is defined as a syndrome in which pancytopenia is accompanied by marrow hypocellularity. The severity of AA, in terms of the 1979 International Aplastic Anemia Study Group guidelines [1], has prognostic significance. An extremely useful recent addition to these criteria is the definition of very severe aplastic anemia (VSAA) by the European Bone Marrow Transplant Group's Severe Aplastic Anemia Working Party [2]. While the prognosis in patients with AA has been improved with refinement of bone marrow transplantation [2] and immunosuppression [3], patients with VSAA, particularly when combined with infection, still have a poor prognosis. The availability of recombinant human granulocyte-macrophage colony-stimulating factor (rhGM-CSF) has enabled the start of numerous trails to investigate the therapeutic value of rhGM-CSF in AA [4–11]. The majority of patients included in these trials did not fulfill the criteria of VSAA, i.e., they had significant residual myelopoiesis. With one exception [5] they were free of infections when entering the study.

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Authors
  1. A. Raghavachar
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  2. W. Hinterberger
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  3. J. P. Kaltwasser
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  4. K. Höffken
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  5. F. Herrmann
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  6. M. Freund
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  7. E. Platzer
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  8. J. Frisch
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  9. H. Heimpel
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  10. N. Frickhofen
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Editor information

Editors and Affiliations

  1. Abteilung Hämatologie und Onkologie, Medizinische Hochschule Hannover, Konstanty-Gutschow-Straße 8, 3000, Hannover 61, Germany

    Mathias Freund  & Hartmut Link  & 

  2. Abteilung Immunologie und Transfusionsmedizin, Medizinische Hochschule Hannover, Konstanty-Gutschow-Straße 8, 3000, Hannover 61, Germany

    Reinhold E. Schmidt

  3. Abteilung Pädiatrische Hämatologie und Onkologie, Kinderklinik, Medizinische Hochschule Hannover, Konstanty-Gutschow-Straße 8, 3000, Hannover 61, Germany

    Karl Welte

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© 1992 Springer-Verlag, Berlin Heidelberg

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Raghavachar, A. et al. (1992). Recombinant Human Granulocyte-Macrophage Colony-Stimulating Factor in Aplastic Anemia: A Phase I/II Trial with Emphasis on Very Severe Neutropenia and Active Infection. In: Freund, M., Link, H., Schmidt, R.E., Welte, K. (eds) Cytokines in Hemopoiesis, Oncology, and AIDS II. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-48715-6_69

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  • DOI: https://doi.org/10.1007/978-3-642-48715-6_69

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-55242-0

  • Online ISBN: 978-3-642-48715-6

  • eBook Packages: Springer Book Archive

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