Influence of Interleukin-3, Granulocyte—Macrophage Colony-Stimulating Factor, and Granulocyte Colony-Stimulating Factor on the Proliferation of Human and Murine Urothelial Tumor Cell Lines
Conference paper
Abstract
Hematopoietic growth factors (GF) have been implicated in regulation and differentiation of hematopoietic precursor cells. One of them, the granulocyte—macrophage colony-stimulating factor (GM-CSF), stimulates production and function of granulocytes and macrophages in vivo. Therefore, in phase I and II studies GM-CSF is used in chemotherapy of advanced transitional cell carcinoma of the bladder in order to minimize therapy-related toxicity as well as to enhance the efficacy of antineoplastic agents in escalated cytostatic therapy for chemotherapeutically refractory urothelial carcinoma [6, 9].
Keywords
Transitional Carcinoma Cell Proliferative Effect Hematopoietic Growth Factor Small Cell Lung Cancer Cell Cell Lung Cancer Cell Line
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References
- 1.Baldwin GC, Gasson JC, Kaufman SE, Quan SG, Williams RE, Avalos BR, Gazdar AF, Golde DW, DiPersio JF (1989) Nonhematopoietic tumor cells express functional GM-CSF receptors. Blood 73: 1033–1037PubMedGoogle Scholar
- 2.Berdel WE, Dannhauser-Riedl S, Serve H, Zafferani M (1991) Extrahematopoietic effects of hematopoietic growth factors on tumor cells in vitro and in vivo. Ann Hematol 62: A4Google Scholar
- 3.Berdel WE, Dannhauser-Riedl S, Steinhauser G, Winton EF (1989) Various human hematopoietic growth factors (Interleukin-3, GM-CSF, G-CSF) stimulate clonal growth of nonhematopoietic tumor cells. Blood 73: 80–83Google Scholar
- 4.Dedhar S, Gaboury L, Galloway P, Eaves C (1989) Human granulocyte-macrophage colony stimulating factor is a growth factor active on an variety of cell types of nonhematopoietic origin. Proc Natl Acad Sci USA 85: 9253–9257CrossRefGoogle Scholar
- 5.Hill BT for the members of the EORTC clonogenic assay screening study group (1991) Human granulocyte macrophage colony stimulating factor modulates in vitro growth in only a minority of continuous human tumor cell lines. Eur J Cancer 27: 231–235Google Scholar
- 6.Gabrilove JL, Jakubowski A, Scher H, Sternberg C, Wong G, Grous J, Yagoda A, Fain K, Moore MAS, Clarkson B, Oettgen HF, Alton K, Welte K, Souza L (1989) Effect of granulocyte colony-stimulating factor on neutropenia and associated morbidity due to chemotherapy for transitional carcinoma of the urothelium. N Engl J Med 318: 1414–1422CrossRefGoogle Scholar
- 7.Griffin JD, Okuda K, Kanakura Y, Druker B (1991) GM-CSF and IL-3 activate multiple cellular kinases. Ann Hematol 62: A11Google Scholar
- 8.Herrmann F, Brach MA, Henschler R, Licht T, Brennscheidt U, Lübbert M, Mertelsmann R (1991) Interaction of hematopoietic cytokines with cytotoxic drugs: implications for the treatment of acute myelogenous leukemia and related disorders. Ann Hematol 62: A23Google Scholar
- 9.Logothetis CJ, Dexeus FH, Sella A, Amato RJ, Kilbourn RG, Finn L, Gutterman JU (1990) Escalated therapy for refractory urothelial tumors: Methotrexate—Vinblastine-DoxorubicinCisplatin plus unglycosylated recombinant human granulocyte—macrophage colony-stimulating factor. JNCI 82: 667–672Google Scholar
- 10.Ohigashi T (1990) Granulocyte colony stimulating factor enhances the cytotoxic effects of methotrexate to bladder cancer cells in vitro. Keio J Med 39: 254–260PubMedCrossRefGoogle Scholar
- 11.Rizzino A, Kazakow P, Ruf E, Kussynski C, Nebelsick J (1988) Inhibitory effects of cell density on the binding of transforming growth factor, epidermal growth factor, platelet derived growth factor and fibroblastic growth factor. Cancer Res 82: 4266–4271Google Scholar
- 12.Ruff MR, Farrar WL, Pert CD (1986) Interferon gamma and granulocyte—macrophage colony stimulating factor inhibit growth and induce antigens characteristic of myeloid differentiation in small cell lung cancer cell lines. Proc Natl Acad Sci USA 83: 6613–6617PubMedCrossRefGoogle Scholar
- 13.Twentyman PR, Wright KA (1991) Failure of GM-CSF to influence the growth of small cell and non small cell lung cancer cell lines in vitro. Eur J Cancer 27: 6–8PubMedCrossRefGoogle Scholar
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