Host Immune Responses to Neural Transplantation: A Possible Model for Autoimmune Diseases of the Central Nervous System

  • R. D. Lund
  • K. Rao
  • T. J. Gill
Conference paper
Part of the Research and Perspectives in Alzheimer’s Disease book series (ALZHEIMER)

Summary

Grafts of embryonic mouse neural tissue can survive transplantation to neonatal rat brains. Some grafts, however, undergo spontaneous rejection by the host immune system, showing that immune privilege in the brain is not absolute. Rejection can also be induced by a peripheral skin graft of mouse origin or by neural degeneration in the region of the graft. In each case, MHC antigen expression is induced in nonneuronal cells, and it is thought that this is responsible for initiating graft rejection. It is suggested that certain degenerative diseases of the brain may follow a similar pattern. Foreign antigens may be inserted into neural cell surfaces as a result of an infection or other transformation. Like the grafts, such cells may survive and function normally until confronted with a set of circumstances in which major histocompatibility complex (MHC) expression is induced. As a result, a sequence of degenerative events may then ensue.

Keywords

Major Histocompatibility Complex Experimental Allergic Encephalomyelitis Immune Privilege Major Histocompatibility Complex Antigen Major Histocompatibility Complex Expression 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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Copyright information

© Springer-Verlag Berlin Heidelberg 1989

Authors and Affiliations

  • R. D. Lund
  • K. Rao
  • T. J. Gill

There are no affiliations available

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