Die Kristallisationshemmkörper im Urin bei Calciumlithiasis

  • J. M. Baumann
  • U. Ganz
  • R. Felix
  • H. Fleisch
  • G. Rutishauser
Conference paper
Part of the Fortschritte der Urologie und Nephrologie book series (2824, volume 5)

Zusammenfassung

Untersuchungen der Urinsättigung bezüglich steinbildender Calciumsalze zeigten, daß der Urin sowohl beim Steingesunden wie beim Steinbildner häufig übersättigt ist (Elliot 1967, Yarbo 1958,Robertson et al. 1968, 1971, Pak 1969). Weshalb nun diese Übersättigung beim Gesunden zu keiner Auskristallisation oder nur zu einer harmlosen Kristallurie, beim Kranken aber zur Bildung von eigentlichen Harnwegskonkrementen führt, konnte bisher nicht befriedigend erklärt werden.

This is a preview of subscription content, log in to check access.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literatur

  1. Chen, P. S., Toribara, T. Y. und Warner, H., Microdetermination of phosphorus. Analyt. Chem. 28, 1756–58, (1956).CrossRefGoogle Scholar
  2. Elliot, J. S. and Ribeiro, M., Calcium oxalate solubility in urine: The state of relative saturation, Invest. Urol. 5, 239–243, (1967).Google Scholar
  3. Fleisch, H. and S. Bisaz, Isolation from urine of pyrophosphate, a calcification inhibitor. Amer. J. Physiol. 203, 671–675, (1962).PubMedGoogle Scholar
  4. Fleisch, H. und S. Bisaz, Die Pyrophosphatausscheidung im Harn beim gesunden Menschen. HeIv. physiol. pharmacol. Acta 21, 88–94 (1963).PubMedGoogle Scholar
  5. Fleisch, H. and S. Bisaz, The inhibitory effect of pyrophosphate on calcium oxalate precipitation and its relation to urolithiasis. Experientia 20, 276–277 (1964).PubMedCrossRefGoogle Scholar
  6. Fleisch, H., S. Bisaz and A. D. Care, Effect of orthophosphate on urinary pyrophosphate excretion and the prevention of urolithiasis. Lancet i, 1065–1067 (1964).CrossRefGoogle Scholar
  7. H. Fleisch and A. Monod, A new technique for measuring aggregation of calcium oxalate crystals in vitro: effect or urine, magnesium, pyrophosphate and diphosphonates. Urinary Calculi. Int. Symp. Renal Stone Res., (madrid, 1972), (Karger, 53–56, 1973 ).Google Scholar
  8. Hodgkinson, A., and L. N. Pyrah, The urinary excretion of calcium and inorganic phosphate in 344 patients with calcium stone of renal origin. Brit. J. Surg. 46, 10–18 (1958).PubMedCrossRefGoogle Scholar
  9. Hodgkinson, A. and Zarembski, P.M, The determination of oxalic acid in urine. Analyst 86, 16–21 (1961).CrossRefGoogle Scholar
  10. Howard, J.E. and W. C. Thomas, Some observations on rachitic rat cartilage of probable significance in the etiology of renal calculi. Transact. Amer. clin.climat. Ass. 70, 94–102 (1958).Google Scholar
  11. Howard, J.E., W.C. Thomas, L.M. Barker, L.H. Smith and C. L. Wadkins, The recognition and isolation of a peptide inhibitor to calcification. Johns Hopkins Med. J. 120, 119–136 (1967).PubMedGoogle Scholar
  12. Kageyama, N., Direct colorimetric determination of uric acid in serum and urine with uricase-catalase-system. Clin. Chim. Acta 31, 421 (1971).PubMedCrossRefGoogle Scholar
  13. Melick, R. A. and P. H. Henneman, Clinical and laboratory studies of 207 consecutive patients in a kidney-stone clinic. N. Engl. J. Med. 259, 307–314 (1958).PubMedCrossRefGoogle Scholar
  14. Pak, C. Y. C., Physicochemical basis for formation of renal stones of calcium phosphate origin: calculation of the degree of saturation of urine with respect to brushite. J. Clin. Invest. 48, 1–9 (1969).CrossRefGoogle Scholar
  15. Robertson, W. G. and M. Peacock, Calcium oxalate crystalluria and inhibitors of crystallization in recurrent renal stone-formers. Clin. Sci. 43, 499–506 (1972).PubMedGoogle Scholar
  16. Robertson, W. G., Peacock, M. and Nordin, B. E. D., Activity products in stone-forming and non-stone-forming urine. Clin. Sci. 34, 579–594 (1968).Google Scholar
  17. Robertson, W. G., M. Peacock and B. E. C. Nordin, Calcium crystalluria in recurrent renal-stone formers. Lancet ii, 21–24 (1969).Google Scholar
  18. Robertson, W G., M. Peacock and B. E. C. Nordin, Calcium oxalate crystalluria and urine saturation in recurrent renal stone formers. Clin. Sci. 40, 365–374 (1971).PubMedGoogle Scholar
  19. Robertson, W G., M. Peacock and B. E. C. Nordin, Inhibitors of the growth and aggregation of calcium oxalate crystals in vitro. Clin. Chim. Acta 43, 31–37 (1973).PubMedCrossRefGoogle Scholar
  20. Russell, R. G. G., Edwards, N A. and Hodgkinson, A., Urinary Pyrophosphate and Urolithiasis. Lancet 1964/I, 1446.Google Scholar
  21. R. G. G. Russell and H. Fleisch, Pyrophosphate and stone formation. In: Renal Stone Res. Symp. (1969). A. Hodgkinson and B. E. C. Nordin (eds.), (Churchill, London).Google Scholar
  22. Smith, L. H. and J. T McCall, Chemical nature of peptide inhibitors isolated from urine. Renal Stone Research Symposium (A. Hodgkinson and B. E. C. Nordin, Eds.), Churchill, London, (1969), p 153.Google Scholar
  23. Vermeulen, C. W., E. S. Lyon and G. H. Miller, Calcium phosphate solubility in urine as measured by a precipitation test: experimental urolithiasis XIII. J. Urol. 79, 596–606 (1958).PubMedGoogle Scholar
  24. Yarbo, C.L., Studies on the solubility of tricalcium phosphate in urine. I. Effect of dilution. J. Urol. 80, 158–160 (1958).Google Scholar
  25. Yarbo, C.L., Studies on the mechanism of formation of renal calculi. II. J. Urol. 80, 10–12 (1958).Google Scholar

Copyright information

© Dr. Dietrich Steinkopff Verlag, Darmstadt 1975

Authors and Affiliations

  • J. M. Baumann
    • 1
  • U. Ganz
    • 1
  • R. Felix
    • 1
  • H. Fleisch
    • 1
  • G. Rutishauser
    • 1
  1. 1.Urolog. Abt. des Bezirksspitals BielPathophysiolog. Institut der Univ.BielSchweiz

Personalised recommendations