Differential Diagnosis of Treatment Sequelae in the Lung

  • Michael Galanski
  • Regine Rathmann
  • Cornelia Schaefer-Prokop
Part of the Medical Radiology book series (MEDRAD)


With the advancement in tumor treatment and the increasing use of potent yet aggressive modalities of tumor therapy, the incidence of therapy-related side effects increases, e.g., drug-induced lung disease. This is especially true for patients treated with chemotherapy (with known lung toxicity) and resultant immunosuppressive effects and/or those treated with radiation of the lungs. Patients with malignant lymphoma, myeloproliferative disease, testicular tumors, chemotherapy-sensitive sarcomas (Ewing, neuroblastoma, rhabdomyosarcoma), HIV-associated tumors, breast cancer or gastrointestinal tumors all belong to this group. If these patients express symptoms such as fever, dyspnea and/or pulmonary infiltrates, it may be considerably difficult to differentiate the various potential causes. However, these difficulties must be overcome in order to induce the correct therapy. Depending on the diagnosis, different and even partially contradictory treatments are the necessary consequence. The definition of diagnosis is impeded for two other reasons: First, the tumor itself may lead to immunodeficiency irrespective of treatment resulting in an increased disposition for infection. Second, due to better treatment modalities, more advanced tumor stages are seen, with unusual tumor manifestations and metastases, and a resultant higher rate of complete response and survival has been achieved. The etiologic spectrum of pulmonary disease has increased, while the morphologic response of lung parenchyma, however, is Stereotypic, such that the clinical and radiographic appearance is rather nonspecific.


High Resolution Compute Tomography Interstitial Edema Radiation Pneumonitis Lymphatic Spread Tumor Manifestation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag Berlin Heidelberg 1995

Authors and Affiliations

  • Michael Galanski
    • 1
  • Regine Rathmann
    • 1
  • Cornelia Schaefer-Prokop
    • 1
  1. 1.Diagnostische Radiologie I, Medizinische Hochschule HannoverHannoverGermany

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