Environmental Hygiene II pp 57-60 | Cite as
Mutagenicity of Carcinogenic Metal Compounds: Molecular Mechanisms
Abstract
Compounds of eight metals/metalloids have been classified as carcinogens by IARC and DFG (Deutsche Forschungsgemeinschaft) (Table 1). IARC (1987) has listed As, Cr(VI), and Ni as human carcinogens, Be and Cd as probable human carcinogens and Pb as possible human carcinogen (compounds of the metals included). The DFG (1989) additionally lists Co and Sb(III) as unequivocal carcinogens by reason of animal experiments. In contrast to organic carcinogens there is little concordance between carcinogenicity and mutagenicity of metal compounds in bacteria. In mammalian call mutagenicity assays, all tested inorganic carcinogens are (weak) mutagens (Miyaki et al., 1979).
Keywords
Metal Compound Human Carcinogen Chromium Reduction High Phosphate Concentration Probable Human CarcinogenPreview
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