Metabolic Effects of the Neurohypophyseal Hormones and Related Polypeptides

  • I. A. Mirsky
Part of the Handbuch der experimentellen Pharmakologie / Handbook of Experimental Pharmacology book series (HEP, volume 23)


There are no known disorders of carbohydrate, fat or protein metabolism in clinical or experimental conditions associated with derangements in neurohypophyseal function. Yet, a very impressive array of reports can be marshalled to demonstrate that the administration of neurohypophyseal extracts may influence a variety of metabolic regulations (Schaumann, 1937; Van Dyke, 1936, 1939; Harris, 1948; Stehle, 1950; Shtjll and Mayer, 1956).


Adipose Tissue Blood Glucose Concentration Plasma Free Fatty Acid Toad Bladder Hyperglycemic Effect 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. Bacq, Z.M., and S. Dworkin: The heart rate after sympathectomy and vagotomy and the blood sugar as affected by posterior hypophyseal extracts (Pitressin and Pitocin). Amer. J. Physiol. 95, 605 (1930).Google Scholar
  2. Baisset, A., L. Dang Tran, et P. Montastrtuc: Action hypoglycémiante de la vasopressine chez le chien surrénalectomisé ou hypophysectomisé. C.R. Soc. Biol. (Paris) 157, 877 (1963).Google Scholar
  3. P. Montastrtuc —: Effets comparés de la vasopressine et de l’ocytocine sur la glycémie du chien normal ou privé de divers systèmes endocriniens. C.R. Soc. Biol. (Paris) 159, 477 (1965).Google Scholar
  4. P. Montastrtuc —: Influence de l’actinomycine D sur l’action hypoglycémiante de la vasopressine chez le chien surrénalectomisé ou hypophysectomisé. C.R. Soc. Biol. (Paris) 160, 1084 (1967).Google Scholar
  5. Balasse, E., et E. Rasio: Action insulino-libératrice de l’ocytocine chez le chien. Arch. Int. Physiol. Biochim. 73, 27 (1965a).PubMedCrossRefGoogle Scholar
  6. —: Mécanisme d’action de l’ocytocine sur la concentration plasmatique des acides gras libres (A.G.L.) chez le chien. Arch. int. Pharmacodyn. 157, 356 (1965b).PubMedGoogle Scholar
  7. —, et V. Conard: Action insulino-mimétique de la vasopressine chez le chien. Arch. int. Pharmacodyn. 161, 392 (1966).PubMedGoogle Scholar
  8. La Barre, J.: A propos des variations glycémiques consécutives à l’administration d’extrait hypophysaire postérieur. Arch. int. Pharmacodyn. 38, 409 (1930).Google Scholar
  9. Bentley, P. J.: Hyperglycémic effect of vasotocin in toads. Nature (Lond.) 206, 1053 (1965).CrossRefGoogle Scholar
  10. —, and B. K. Follett: The effects of hormones on the carbohydrate metabolism of the Lamprey Lampetra Fluviatilis. J. Endocr. 31, 127 (1965).PubMedCrossRefGoogle Scholar
  11. Bergen, S.S., R. Sullivan, J.G. Hilton, S.W. Willis Jr., and T.B. Van Itallie: Glycogeno-lytic effect of vasopressin in the canine liver. Amer. J. Physiol. 199, 136 (1960).PubMedGoogle Scholar
  12. Bierman, E.L., I.L. Schwartz, and V.P. Dole: Action of insulin on release of fatty acids from tissue stores. Amer. J. Physiol. 191, 359 (1957).PubMedGoogle Scholar
  13. Blix, G., u. C.A. Ohlin: Pituitrin und Blutlipoide. Skand. Arch. Physiol. 51, 167 (1927).CrossRefGoogle Scholar
  14. Blotner, H., and R. Frrz: The effect of insulin, pituitrin and adrenalin on the blood-sugar level. J. clin. Invest. 5, 51 (1927).PubMedCrossRefGoogle Scholar
  15. Borchardt, L.: Experimentelles über den Diabetes bei der Akromegalie. Dtsch. med. Wschr. 34, 946 (1908).Google Scholar
  16. Burn, J. H.: The modification of the action of insulin by pituitary extract and other substances. J. Physiol. (Lond.) 57, 318 (1923).Google Scholar
  17. Burt, R. L.: Influence of sex and gonadal function on metabolic effects of oxytocin. Obstet. and Gynec. 24, 559 (1964).Google Scholar
  18. —, and N.H. Lease: Metabolic activity of oxytocin. Preliminary observations. Obstet, and Gynec. 20, 442 (1962).Google Scholar
  19. —, and W.N. Dannenburg: Effect of synthetic oxytocin on plasma nonesterified fatty acids, triglycerides and blood glucose. Obstet, and Gynec. 21, 708 (1963).Google Scholar
  20. W.N. Dannenburg —: Comparative metabolic effects of certain oxytocic preparations and related compounds on blood glucose and plasma Nefa. Obstet, and Gynec. 23, 574 (1964a).Google Scholar
  21. W.N. Dannenburg —: Sex differences in metabolic effects of oxytocin. Nature (Lond.) 201, 829 (1964b).CrossRefGoogle Scholar
  22. Cahill, Jr., G. F., B. Jeanrenaud, B. Le Boeuf, and A.E. Renold: Effects of insulin on adipose tissue. Ann. N.Y. Acad. Sci. 82, 403 (1959).CrossRefGoogle Scholar
  23. Camu, F., et V. Conard: Effet de l’ocytocine sur l’inactivation de l’insuline par le rein de rat normal in vitro. Arch. int. Pharmacodyn. 162, 247 (1966).PubMedGoogle Scholar
  24. Cash, W.D., and M.H. Kaplan: Comparison of 8-lysine-vasopressin, l-deamino-8-lysine-vasopressin and l-acetyl-8-lysine-vasopressin on the blood glucose level in rabbits. Endocrinology 74, 803 (1964).PubMedCrossRefGoogle Scholar
  25. Chaudhury, R.R., and P.P. Nayyar: The hyperglycemic action of synthetic oxytocin. Toxi-col. appl. Pharmacol. 4, 174 (1962).CrossRefGoogle Scholar
  26. Cohen, J., A.R. Brenneman, and Y.J. Topper: The stimulation by oxytocin and acetyl-choline of glucose oxidation by lactating — rat mammary — gland slices: Inhibition of the hormone effects by puromycin. Biochim. biophys. Acta (Amst.) 63, 554 (1962).CrossRefGoogle Scholar
  27. Coope, R., and E.N. Chamberlain: The effects of pituitrin on the fatty acid of the liver. J. Physiol. (Lond.) 60, 67 (1925).Google Scholar
  28. Cushing, H.: The pituitary body and its disorders. Philadelphia: Lippincott 1910.Google Scholar
  29. Draper, W.B., and R.M. Hill: Pituitary extract and the CO2 combining power of the blood plasma. Proc. Soc. exp. Biol. (N.Y.) 27, 33 (1929).Google Scholar
  30. Van Dyke, H. B.: The physiology and pharmacology of the pituitary body. Vols 1 and 2. Chicago: University of Chicago Press 1936 and 1939.Google Scholar
  31. Estes Jr., E. H., M. D. Bogdonoff, S. J. Friedberg, W. R. Harlan, and D. L. Trout: The effect of insulin on nonesterified fatty acid release from the human leg. J. clin. Invest. 38, 2131 (1959).PubMedCrossRefGoogle Scholar
  32. Friesen, H.G., and E.B. Astwood: Changes in neurohypophyseal proteins induced by dehydration and ingestion of saline. Endocrinology 80, 278 (1967).PubMedCrossRefGoogle Scholar
  33. Geiling, E.M.K., and C.A. Eddy: The hyperglycémie effect of vasopressin, oxytocin and pituitrin. Proc. Soc. exp. Biol. (N.Y.) 26, 146 (1928).Google Scholar
  34. Di Girolama, M., D. Rtjdman, M. Reid, and F. Seidman: Effect of pituitary hormones upon serum fatty acid concentration of the rabbit. Endocrinology 68, 457 (1961).CrossRefGoogle Scholar
  35. Goldman, J. K.: Effect of pitressin infusion on plasma free fatty acid levels in man. Proc. Soc. exp. Biol. (N.Y.) 117, 164 (1964).Google Scholar
  36. Goodfriend, T., and J. Kirkpatrick: Effect of neurohypophyseal hormones on oxidative metabolism of the toad bladder in vitro. Endocrinology 72, 742 (1963).PubMedCrossRefGoogle Scholar
  37. —, and Y.J. Topper: Effects of oxytocin, vasopressin and acetylcholine on glucose metabolism in mammary tissue in vitro. J. biol. Chem. 236, 1241 (1961).PubMedGoogle Scholar
  38. Goodman, H. M.: Effects of insulin on water uptake by adipose tissue during incubation in vitro. Endocrinology 76, 531 (1965).PubMedCrossRefGoogle Scholar
  39. Gordon Jr., R.S., and A. Cherkes: Unesterified fatty acid in human blood plasma. J. clin. Invest. 35, 206 (1956).PubMedCrossRefGoogle Scholar
  40. —: Production of unesterified fatty acids from isolated rat adipose tissue incubated in vitro. Proc. Soc. exp. Biol. (N.Y.) 97, 150 (1958).Google Scholar
  41. Gurd, M. R.: The effect of oxytocin and vasopressin on the action of insulin. Quart. J. Pharm. 7, 661 (1934).Google Scholar
  42. Hannon, J.P., and A.M. Larson: Fatty acid metabolism during norepinephrine induced thermogenesis in the cold-acclimatized rat. Amer. J. Physiol. 203, 1055 (1962).PubMedGoogle Scholar
  43. Harris, G.W.: Neural control of the pituitary gland. Physiol. Rev. 28, 139 (1948).PubMedGoogle Scholar
  44. Heidenreich, O., Y. Kook, L. Baumeister u. P. Keller: Untersuchungen über die Wirkungsweise der Hypophysenhinterlappenhormone auf den Kohlenhydrat-und Fettstoffwechsel. Naunyn-Schmiedebergs Arch. exp. Path. Pharmak. 245, 321 (1963).Google Scholar
  45. — u. E. Reus: Quantitative Untersuchungen über die blutzuckersteigernde Wirkung von synthetischem Oxytocin und Vasopressin sowie über das Auftreten dieses Hormoneffektes unter physiologischen Bedingungen. Naunyn-Schmiedebergs Arch. exp. Path. Pharmak. 243, 136 (1962).Google Scholar
  46. Horowitz, I., J. C. Beck, and D. Rubinstein: The effect of vasopressin on lipogenesis in vitro. J. biol. Chem. 241, 1031 (1966).PubMedGoogle Scholar
  47. Houssay, B.A., et E. Di Benedetto: Action hyperglycémiante de l’extrait réptropituitaire. C.R. Soc. Biol. (Paris) 114, 793 (1933).Google Scholar
  48. Itoh, S., M. Tsukada, A. Okuno, and T. Yoshinari: Effects of vasopressin on the plasma concentration of free fatty acids and in vitro oxygen consumption of tissues of the rat. Jap. J. Physiol. 16, 23 (1966).CrossRefGoogle Scholar
  49. Kook, Y., K.B. Cho, and K.O. Yun: Metabolic effects of oxytocin in the chicken. Nature (Lond.) 204, 385 (1964).CrossRefGoogle Scholar
  50. Krahl, M.E.: Specificity of insulin or oxytocin stimulation of protein synthesis in adipose tissue. Amer. J. Physiol. 207, 1169 (1964).PubMedGoogle Scholar
  51. Long, C.N.H., E. Hill, and F. Bischoff: The posterior pituitary hormone in metabolism. III. The effect of pitressin and pituitrin upon the lipoid distribution. Amer. J. Physiol. 102, 402 (1932).Google Scholar
  52. Migliovini, R.H., and C. Linder: Oxytocin and lipogenesis by adipose tissue in vitro. Bio-chim. biophys. Acta (Amst.) 125, 392 (1966).CrossRefGoogle Scholar
  53. Mirsky, I.A.: Effect of oxytocin on plasma free fatty acids on non-diabetic and diabetic dogs. Proc. Soc. exp. Biol. (N.Y.) 110, 42 (1962).Google Scholar
  54. —: Effect of oxytocin, vasopressin, and related peptides on plasma FFA of non-diabetic and diabetic dogs. Amer. J. Physiol. 204, 842 (1963a).Google Scholar
  55. —: Relative effects of insulin, oxytocin and vasopressin on the free fatty acid concentration of the plasma of non-diabetic and diabetic dogs. Endocrinology 73, 613 (1963b).PubMedCrossRefGoogle Scholar
  56. —: Effect of biologically active peptides on adipose tissue. Handbook of physiology — Adipose tissue. American Physiological Society, Washington, D.C., 1965, p. 407.Google Scholar
  57. —, and G. Perisutti: Insulinase-inhibitory activity of protein hydrolysates. Proc. Soc. exp. Biol. (N.Y.) 94, 589 (1957).Google Scholar
  58. —: The insulin-like action of oxytocin on adipose tissue. Biochim. biophys. Acta (Amst.) 50, 603 (1961).CrossRefGoogle Scholar
  59. —: The action of oxytocin and related peptides on epididymal adipose tissue of the rat. Endocrinology 71, 158 (1962).PubMedCrossRefGoogle Scholar
  60. Okuno, A., M. Yamamoto, and S. Itoh: Lowering of the body temperature induced by vasopressin. Jap. J. Physiol. 15, 378 (1965).CrossRefGoogle Scholar
  61. Pittman, J. A., B.R. Boshell, B.H. Williams, D. Hamner, and P. Hill: Insulin-like activity of vasopressin and oxytocin. Biochem. biophys. Res. Commun. 6, 29 (1961).PubMedCrossRefGoogle Scholar
  62. Raab, W.: The role of the pituitary posterior hormone in fat metabolism. Endocrinology 14, 385 (1930).CrossRefGoogle Scholar
  63. Renold, A.E., and G.F. Cahill Jr.: Metabolism of isolated adipose tissue: A summary. Handbook of physiology — Adipose tissue. American Physiological Society, Washington, D.C., 1965, p. 483.Google Scholar
  64. Rodbell, M.: Metabolism of isolated fat cells. I. Effects of hormones on glucose metabolism and lipolysis. J. biol. Chem. 239, 375 (1964).PubMedGoogle Scholar
  65. Rudman, D., S. J. Brown, and M.F. Malkin: Adipokinetic actions of adrenocorticotropin, thyroid-stimulating hormone, vasopressin, α-and β-melanocyte-stimulating hormones, fraction H, epinephrine and norepinephrine in the rabbit, guinea-pig, hamster, rat, pig and dog. Endocrinology 72, 527 (1963).CrossRefGoogle Scholar
  66. —, R.L. Hirsch, F.F. Kendall, F. Seidman, and S. J. Brown: An adipokinetic component of the pituitary gland: purification, physical, chemical and biological. Recent Progr. Hormone Res. 18, 89 (1962).Google Scholar
  67. Schaumann, O.: Heffter’s Handbuch der experimentellen Pharmakologie. Berlin 1937.Google Scholar
  68. Schroeder, H.: Über die blutzuckersteigernde und insulinantagonistische Wirkung des Tone-phins bzw. Pitressins und Orasthins. Klin. Wschr. 12, 1766 (1933).CrossRefGoogle Scholar
  69. Seifter, J., and D.H. Baeder: Lipid mobilizer (LM) from posterior pituitary of hogs in rat adipose tissue. Proc. Soc. exp. Biol. (N.Y.) 95, 318 (1957).Google Scholar
  70. Shull, K.H., and J. Mayer: Experimental hyperglycémic states not primarily due to a lack of insulin. Vitam. u. Horm. 14, 187 (1956).CrossRefGoogle Scholar
  71. Silver, S., u. E. Mislowitzer: Studien über die Adrenalinhyperglykämie. II. Mitt. Die Beeinflussung der Adrenalinhyperglykämie durch die getrennten Hypophysenhinterlappen-substanzen. Z. ges. exp. Med. 78, 741 (1931).CrossRefGoogle Scholar
  72. Stehle, R. L.: The physiological actions of the hormones of the posterior lobe of the pituitary gland. Vitam. u. Horm. 8, 215 (1950).CrossRefGoogle Scholar
  73. Steinberg, D., P.J. Nestel, E.R. Buskirk, and R.H. Thompson: Calorigenic effect of norepinephrine correlated with plasma free fatty acid turnover and oxidation. J. clin. Invest. 43, 167 (1964).PubMedCrossRefGoogle Scholar
  74. Stenstrom, T.: Das Pituitrin und die Adrenalinhyperglykämie. Biochem. Z. 58, 472 (1913).Google Scholar
  75. Thaddea, S.: Über Beziehungen der isolierten Hypophysenhinterlappenhormone zum Kohlehydratstoffwechsel beim Menschen. Z. klin. Med. 125, 175 (1933).Google Scholar
  76. —, u. A. Waly: Zur Frage der Wirkungsweise und des Angriffspunktes der isolierten Hypophysenhinterlappenhormone auf den Kohlehydratstoffwechsel. Arch. Exptl. Pathol. Phar-makol. 172, 535 (1933).CrossRefGoogle Scholar
  77. Tsukada, M., A. Okuno, and S. Itoh: Influence of vasopressin on the metabolic rate in rats. Jap. J. Physiol. 15, 388 (1965).CrossRefGoogle Scholar
  78. Vaisler, L., E. Costiner, and C. Gheorghin: Actiunea hyperglicemianta a oxitocinei in siste-mul de fiscat perfuzat in vitro. Stud. Cercet. Endocr. 16, 557 (1965).PubMedGoogle Scholar
  79. Vaughan, M.: Effects of pitressin on lipolysis and on phosphorylase activity in rat adipose tissue. Amer. J. Physiol. 207, 1166 (1964).PubMedGoogle Scholar
  80. White, J. E., and F.L. Engel: Lypolytic action of corticotropin on rat adipose tissue in vitro. J. clin. Invest. 37, 1556 (1958).PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1968

Authors and Affiliations

  • I. A. Mirsky

There are no affiliations available

Personalised recommendations