D-Cycloserine and O-Carbamyl-D-serine

  • Francis C. Neuhaus
Chapter
Part of the Antibiotics book series (ANTIBIOTICS, volume 1)

Abstract

Alanine is a major component of the peptidoglycan (mucopeptide) and teichoic acid moieties of bacterial cell walls (Salton, 1964). Part of the alanine in the wall is present as the D-isomer (39–50% in Streptococcus faecalis (Ikawa and Snell, 1960; Toennies and Shockman, 1959) and 67% in Staphylococcus aureus (Strominger et al., 1959). Salton (1961) has proposed that the occurrence of D-amino acids in the wall renders the bacterium resistant to proteolytic enzymes. Thus, it may be argued that the introduction of D-amino acids, e.g. D-alanine and D-glutamic acid, into the bacterial wall is a protective mechanism that the bacterium possesses against its environment.

Keywords

Schiff Base Mycobacterium Tuberculosis Pyridoxal Phosphate Alcaligenes Faecalis Alanine Racemase 
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© Springer-Verlag Berlin · Heidelberg 1967

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  • Francis C. Neuhaus

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