Overview on Injectable Fillers: Efficacy and Safety

  • Berthold Rzany


In contrast to the USA, in most countries in Europe and South America, a great variety of injectable fillers are available. Therefore, not only for novices but also for experienced users it can sometimes be quite difficult to decide which filler to use. This chapter will give a brief overview on some of the most commonly used present and past injectable fillers. The selection of products reflects the interest of the authors and might appear arbitrary to someone familiar with other fillers.


Hyaluronic Acid Nodule Formation Human Collagen Granulomatous Reaction Bovine Collagen 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


  1. Alcalay J et al (2003) Late-onset granulomatous reaction to Artecoll. Dermatol Surg 29(8):859–862PubMedCrossRefGoogle Scholar
  2. Andre P (2004) Evaluation of the safety of a non-animal stabilized hyaluronic acid (NASHA – Q-Medical, Sweden) in European countries: a retrospective study from 1997 to 2001. J Eur Acad Dermatol Venereol 18(4):422–425PubMedCrossRefGoogle Scholar
  3. Apte RS et al (2003) Acute choroidal infarction following subcutaneous injection of micronized dermal matrix in the forehead region. Retina 23(4):552–554PubMedCrossRefGoogle Scholar
  4. Ascher B, Bayerl C, Brun P, Kestemont P, Rzany B, Poncet M, Guennoun M, Podda M (2011) Efficacy and safety of a new hyaluronic acid dermal filler in the treatment of severe nasolabial lines – 6-month interim results of a randomized, evaluator-blinded, intra-individual comparison study. J Cosmet Dermatol 10:94–98PubMedCrossRefGoogle Scholar
  5. Avery C, Clifford N (2010) Foreign body granulomatous reaction of the temporal region following dermal filler administration. Br J Oral Maxillofac Surg 48(6):488, Epub 2010 Jul 7PubMedCrossRefGoogle Scholar
  6. Baumann L (2004) CosmoDerm/CosmoPlast (human bioengineered collagen) for the aging face. Facial Plast Surg 20(2):125–128CrossRefGoogle Scholar
  7. Baumann LS, Shamban AT, Lupo MP, Monheit GD, Thomas JA, Murphy DK, Walker PS, Juvéderm vs. Zyplast Nasolabial Fold Study Group (2007) Comparison of smooth-gel hyaluronic acid dermal fillers with cross-linked bovine collagen: a multicenter, double-masked, randomized, within-subject study. Dermatol Surg 33(Suppl 2):S128–S135Google Scholar
  8. Bergeret-Galley C et al (2001) The value of a new filler material in corrective and cosmetic surgery: Dermalive and Dermadeep. Aesthetic Plast Surg 25(4):249–255Google Scholar
  9. Bjarnsholt T, Tolker-Nielsen T, Givskov M, Janssen M, Christensen LH (2009) Detection of bacteria by fluorescence in situ hybridization in culture-negative soft tissue filler lesions. Dermatol Surg 35(Suppl 2):1620–1624, Epub 2009 Aug 26PubMedCrossRefGoogle Scholar
  10. Brandt FS, Cazzaniga A, Baumann L, Fagien S, Glazer S, Kenkel JM, Lowe NJ, Monheit GD, Narins RS, Rendon MI, Rohrich RJ, Werschler WP (2011) Investigator global evaluations of efficacy of injectable poly-L-lactic acid versus human collagen in the correction of nasolabial fold wrinkles. Aesthet Surg J 31(5):521–528PubMedCrossRefGoogle Scholar
  11. Braun M, Braun S (2008) Nodule formation following lip augmentation using porcine collagen-derived filler. J Drugs Dermatol 7(6):579–581PubMedGoogle Scholar
  12. Breiting V et al (2004) A study on patients treated with polyacrylamide hydrogel injection for facial corrections. Aesthetic Plast Surg 28(1):45–53PubMedCrossRefGoogle Scholar
  13. Callan P, Goodman GJ, Carlisle I, Liew S, Muzikants P, Scamp T, Halstead MB, Rogers JD (2013) Efficacy and safety of a hyaluronic acid filler in subjects treated for correction of midface volume deficiency: a 24 month study. Clin Cosmet Investig Dermatol 6:81–89PubMedCentralPubMedCrossRefGoogle Scholar
  14. Cassuto D (2009) The use of Dermicol-P35 dermal filler for nonsurgical rhinoplasty. Aesthet Surg J 29:S22–S24PubMedCrossRefGoogle Scholar
  15. Cohen SR, Berner CF, Busso M, Gleason MC, Hamilton D, Holmes RE, Romano JJ, Rullan PP, Thaler MP, Ubogy Z, Vecchione TR (2006) ArteFill: a long-lasting injectable wrinkle filler material–summary of the U.S. Food and Drug Administration trials and a progress report on 4- to 5-year outcomes. Plast Reconstr Surg 118(Suppl 3):64S–76SPubMedCrossRefGoogle Scholar
  16. Cohen SR, Holmes RE (2004) Artecoll: a long-lasting injectable wrinkle filler material: report of a controlled, randomized, multicenter clinical trial of 251 subjects. Plast Reconstr Surg 114(4):964–976; discussion 977–9PubMedCrossRefGoogle Scholar
  17. Comite SL et al (2004) Treatment of HIV-associated facial lipoatrophy with Radiance FN (Radiesse). Dermatol Online J 10(2):2PubMedGoogle Scholar
  18. Cooperman LS et al (1985) Injectable collagen: a six-year clinical investigation. Aesthetic Plast Surg 9(2):145–151PubMedCrossRefGoogle Scholar
  19. De Boulle K, Swinberghe S, Engman M, Shoshani D (2009) Lip augmentation and contour correction with a ribose cross-linked collagen dermal filler. J Drugs Dermatol 8:1–8PubMedGoogle Scholar
  20. De Cassia Novaes W, Berg A (2003) Experiences with a new nonbiodegradable hydrogel (Aquamid): a pilot study. Aesthetic Plast Surg 27(5):376–380PubMedCrossRefGoogle Scholar
  21. Eccleston D, Murphy DK (2012) Juvéderm Volbella™ in the perioral area: a 12-month prospective, multicenter, open-label study. Clin Cosmet Investig Dermatol 5:167–172PubMedCentralPubMedGoogle Scholar
  22. Ersek RA et al (1997) Bioplastique at 6 years: clinical outcome studies. Plast Reconstr Surg 100(6):1570–1574PubMedCrossRefGoogle Scholar
  23. Fagien S (2000) Facial soft-tissue augmentation with injectable autologous and allogeneic human tissue collagen matrix (autologen and dermalogen). Plast Reconstr Surg 105(1):362–373; discussion 374–375PubMedCrossRefGoogle Scholar
  24. Feeney JN, Fox JJ, Akhurst T (2009) Radiological impact of the use of calcium hydroxylapatite dermal fillers. Clin Radiol 64(9):897–902, Epub 2009 Jul 5PubMedCrossRefGoogle Scholar
  25. Fernandez-Acenero MJ et al (2003) Granulomatous foreign body reaction against hyaluronic acid: report of a case after lip augmentation. Dermatol Surg 29(12):1225–1226PubMedCrossRefGoogle Scholar
  26. Ficarra G et al (2002) Silicone granuloma of the facial tissues: a report of seven cases. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 94(1):65–73PubMedCrossRefGoogle Scholar
  27. Friedman PM et al (2002) Safety data of injectable nonanimal stabilized hyaluronic acid gel for soft tissue augmentation. Dermatol Surg 28(6):491–494PubMedCrossRefGoogle Scholar
  28. Fulton J, Caperton C (2012) The optimal filler: immediate and long-term results with emulsified silicone (1,000 centistokes) with cross-linked hyaluronic acid. J Drugs Dermatol 11(11):1336–1341PubMedGoogle Scholar
  29. George DA, Erel E, Waters R (2012) Patient satisfaction following Bio-Alcamid injection for facial contour defects. J Plast Reconstr Aesthet Surg 65:1622–1626PubMedCrossRefGoogle Scholar
  30. Goldberg DJ (2009) Correction of tear trough deformity with novel porcine collagen dermal filler (Dermicol-P35). Aesthet Surg J 29:S9–S11PubMedCrossRefGoogle Scholar
  31. Grunebaum LD, Elsaie ML, Kaufman J (2010) Six-month, double-blind, randomized, split-face study to compare the efficacy and safety of calcium hydroxylapatite (CaHA) mixed with lidocaine and CaHA alone for correction of nasolabial fold wrinkles. Dermatol Surg 36(S1):760–765CrossRefGoogle Scholar
  32. Hevia O (2009) Six-year experience using 1,000-centistoke silicone oil in 916 patients for soft-tissue augmentation in a private practice setting. Dermatol Surg 35(Suppl 2):1646–1652PubMedCrossRefGoogle Scholar
  33. Homicz MR, Watson D (2004) Review of injectable materials for soft tissue augmentation. Facial Plast Surg 20(1):21–29PubMedCrossRefGoogle Scholar
  34. Huh SY, Cho S, Kim KH, An JS, Won CH, Chang SE, Lee MW, Choi JH, Moon KC (2010) A case of complication after matridex(r) injection. Ann Dermatol 22(1):81–84PubMedCentralPubMedCrossRefGoogle Scholar
  35. Jones D, Murphy DK (2013) Volumizing hyaluronic acid filler for midface volume deficit: 2-year results from a pivotal single-blind randomized controlled study. Dermatol Surg. 2013 Oct 4. [Epub ahead of print]Google Scholar
  36. Kim YJ, Choi KS (2013) Bilateral blindness after filler injection. Plast Reconstr Surg 131(2):298e–299ePubMedCrossRefGoogle Scholar
  37. Landau M (2009) Lip augmentation and rejuvenation using Dermicol-P35 30G: personal experiences from my clinic. Aesthet Surg J. 29(3 Suppl):S12–15Google Scholar
  38. Lemperle G et al (1998) PMMA-Microspheres (Artecoll) for long-lasting correction of wrinkles: refinements and statistical results. Aesthetic Plast Surg 22(5):356–365PubMedCrossRefGoogle Scholar
  39. Lemperle G et al (2003) Soft tissue augmentation with artecoll: 10-year history, indications, techniques, and complications. Dermatol Surg 29(6):573–587; discussion 587PubMedCrossRefGoogle Scholar
  40. Lombardi T et al (2004) Orofacial granulomas after injection of cosmetic fillers. Histopathologic and clinical study of 11 cases. J Oral Pathol Med 33(2):115–120PubMedCrossRefGoogle Scholar
  41. Lowe NJ (2003) Arterial embolization caused by injection of hyaluronic acid (Restylane). Br J Dermatol 148(2):379; author reply 379–380PubMedCrossRefGoogle Scholar
  42. Lowe NJ et al (2001) Hyaluronic acid skin fillers: adverse reactions and skin testing. J Am Acad Dermatol 45(6):930–933PubMedCrossRefGoogle Scholar
  43. Lupo MP, Smith SR, Thomas JA, Murphy DK, Beddingfield FC 3rd (2008) Effectiveness of Juvéderm Ultra Plus dermal filler in the treatment of severe nasolabial folds. Plast Reconstr Surg 121(1):289–297PubMedCrossRefGoogle Scholar
  44. Lupton JR, Alster TS (2000) Cutaneous hypersensitivity reaction to injectable hyaluronic acid gel. Dermatol Surg 26(2):135–137PubMedCrossRefGoogle Scholar
  45. Man J, Rao J, Goldman M (2008) A double-blind, comparative study of nonanimalstabilized hyaluronic acid versus human collagen for tissue augmentation of the dorsal hands. Dermatol Surg 34:1026–1031Google Scholar
  46. Manna F et al (1999) Comparative chemical evaluation of two commercially available derivatives of hyaluronic acid (hylaform from rooster combs and restylane from streptococcus) used for soft tissue augmentation. J Eur Acad Dermatol Venereol 13(3):183–192PubMedGoogle Scholar
  47. Marmur E, Green L, Busso M (2010) Controlled, randomized study of pain levels in subjects treated with calcium hydroxylapatite premixed with lidocaine for correction of nasolabial folds. Dermatol Surg 36:309–315PubMedCrossRefGoogle Scholar
  48. Marmur ES, Taylor SC, Grimes PE, Boyd CM, Porter JP, Yoo JY (2009) Six-month safety results of calcium hydroxylapatite for treatment of nasolabial folds in Fitzpatrick skin types IV to VI. Dermatol Surg 35(Suppl 2):1641–1645PubMedCrossRefGoogle Scholar
  49. Massone C, Horn M, Kerl H, Ambros-Rudolph CM, Giovanna Brunasso AM, Cerroni L (2009) Foreign body granuloma due to Matridex injection for cosmetic purposes. Am J Dermatopathol 31(2):197–199PubMedCrossRefGoogle Scholar
  50. Matti BA, Nicolle FV (1990) Clinical use of Zyplast in correction of age- and disease-related contour deficiencies of the face. Aesthetic Plast Surg 14(3):227–234PubMedCrossRefGoogle Scholar
  51. Micheels P (2001) Human anti-hyaluronic acid antibodies: is it possible? Dermatol Surg 27(2):185–191PubMedCrossRefGoogle Scholar
  52. Moers-Carpi M et al (2007) A multicenter, randomized trial comparing calcium hydroxylapatite to two hyaluronic acids for treatment of nasolabial folds. Dermatol Surg 33(Suppl 2):S144–S151PubMedCrossRefGoogle Scholar
  53. Moers-Carpi MM, Tufet JO (2008) Calcium hydroxylapatite versus nonanimal stabilized hyaluronic acid for the correction of nasolabial folds: a 12-month, multicenter, prospective, randomized, controlled, split-face trial. Dermatol Surg 34(2):210–215PubMedCrossRefGoogle Scholar
  54. Monstrey SJ, Pitaru S, Hamdi M, Van Landuyt K, Blondeel P, Shiri J, Goldlust A, Shoshani D (2007) A two-stage phase I trial of Evolence30 collagen for soft-tissue contour correction. Plast Reconstr Surg 120:303–311PubMedCrossRefGoogle Scholar
  55. Moody BR, Sengelmann RD (2000) Self-limited adverse reaction to human-derived collagen injectable product. Dermatol Surg 26(10):936–938PubMedCrossRefGoogle Scholar
  56. Moyle GJ et al (2004) A randomized open-label study of immediate versus delayed polylactic acid injections for the cosmetic management of facial lipoatrophy in persons with HIV infection. HIV Med 5(2):82–87PubMedCrossRefGoogle Scholar
  57. Nadarajah JT, Collins M, Raboud J, Su D, Rao K, Loutfy MR, Walmsley S (2012) Infectious Complications of Bio-Alcamid Filler Used for HIV-Related Facial Lipoatrophy. Clin Infect Dis 55:1568–1574PubMedCrossRefGoogle Scholar
  58. Narins RS et al (2003) A randomized, double-blind, multicenter comparison of the efficacy and tolerability of Restylane versus Zyplast for the correction of nasolabial folds. Dermatol Surg 29(6):588–595PubMedCrossRefGoogle Scholar
  59. Narins RS, Baumann L, Brandt FS, Fagien S, Glazer S, Lowe NJ, Monheit GD, Rendon MI, Rohrich RJ, Werschler WP (2010a) A randomized study of the efficacy and safety of injectable poly-L-lactic acid versus human-based collagen implant in the treatment of nasolabial fold wrinkles. J Am Acad Dermatol 62(3):448–462PubMedCrossRefGoogle Scholar
  60. Narins RS, Brandt FS, Lorenc ZP, Maas CS, Monheit GD, Smith SR (2008) Twelve-month persistency of a novel ribose-cross-linked collagen dermal filler. Dermatol Surg 34(Suppl 1):S31–S39PubMedCrossRefGoogle Scholar
  61. Narins RS, Brandt FS, Lorenc ZP, Maas CS, Monheit GD, Smith SR, McIntyre S (2007) A randomized, multicenter study of the safety and efficacy of Dermicol-P35 and non-animal-stabilized hyaluronic acid gel for the correction of nasolabial folds. Dermatol Surg 33(Suppl 2):S213–S221; discussion S21PubMedCrossRefGoogle Scholar
  62. Narins RS, Coleman WP 3rd, Rohrich R, Monheit G, Glogau R, Brandt F, Bruce S, Colen L, Dayan S, Jackson I, Maas C, Rivkin A, Sclafani A, Spivak JC (2010b) 12-Month controlled study in the United States of the safety and efficacy of a permanent 2.5 % polyacrylamide hydrogel soft-tissue filler. Dermatol Surg 36(Suppl 3):1819–1829PubMedCrossRefGoogle Scholar
  63. Narins RS, Coleman W, Donofrio L, Jones DH, Maas C, Monheit G, Kaur M, Grundy SL, Pappert EJ, Hardas B (2010c) Nonanimal sourced hyaluronic acid-based dermal filler using a cohesive polydensified matrix technology is superior to bovine collagen in the correction of moderate to severe nasolabial folds: results from a 6-month, randomized, blinded, controlled, multicenter study. Dermatol Surg 36(1):730–740CrossRefGoogle Scholar
  64. Nast A, Reytan N, Hartmann V, Pathirana D, Bachmann F, Erdmann R, Rzany B (2011) Efficacy and durability of two hyaluronic acid-based fillers in the correction of nasolabial folds: results of a prospective, randomized, double-blind, actively controlled clinical pilot study. Dermatol Surg 37:768–775PubMedCrossRefGoogle Scholar
  65. Orentreich DS (2000) Liquid injectable silicone: techniques for soft tissue augmentation. Clin Plast Surg 27(4):595–612PubMedGoogle Scholar
  66. Palm MD, Woodhall KE, Butterwick KJ, Goldman MP (2010) Cosmetic use of poly-l-lactic acid: a retrospective study of 130 patients. Dermatol Surg 36:161–170PubMedCrossRefGoogle Scholar
  67. Perry CM (2004) Poly-L-lactic acid. Am J Clin Dermatol 5(5):361–366; discussion 367–368PubMedCrossRefGoogle Scholar
  68. Pinsky MA, Thomas JA, Murphy DK, Walker PS, Juvéderm vs. Zyplast Nasolabial Fold Study Group (2008) Juvéderm injectable gel: a multicenter, double-blind, randomized study of safety and effectiveness. Aesthet Surg J 28(1):17–23. doi: 10.1016/j.asj.2007.09.005 PubMedCrossRefGoogle Scholar
  69. Protopapa C et al (2003) Bio-Alcamid in drug-induced lipodystrophy. J Cosmet Laser Ther 5(3–4):226–230PubMedCrossRefGoogle Scholar
  70. Rapaport MJ et al (1996) Injectable silicone: cause of facial nodules, cellulitis, ulceration, and migration. Aesthetic Plast Surg 20(3):267–276PubMedCrossRefGoogle Scholar
  71. Raulin C et al (2000) Exudative granulomatous reaction to hyaluronic acid (Hylaform). Contact Dermatitis 43(3):178–179PubMedGoogle Scholar
  72. Requena C et al (2001) Adverse reactions to injectable aesthetic microimplants. Am J Dermatopathol 23(3):197–202PubMedCrossRefGoogle Scholar
  73. Rossner F, Roßner M, Hartmann V, Erdmann R, Wiest LG, Rzany B (2009a) Decrease of reported adverse events to injectable polylactic acid after recommending an increased dilution: eight year results from the Injectable Filler Safety-Study (IFS-Study). J Cosmet Dermatol 8(1):14–18Google Scholar
  74. Rossner M, Roßner F, Bachmann F, Wiest L, Rzany B (2009b) Increased risk of severe adverse reactions towards an injectable filler composed of a fixed combination of methacrylate particles and hyaluronic acid (Dermalive®). Dermatol Surg 35(Suppl 1):367–374Google Scholar
  75. Rzany B et al (2004) Anwendung von Polymilchsäure (New-Fill) in der Ästhetischen Medizin: Ergebnisse des ersten deutschen Konsensustreffens an der Charité. Ästhetische Dermatologie 3Google Scholar
  76. Rzany B, Hilton S, Prager W, Hartmann V, Brandl G, Fischer TC, Gekeler O, Glöckner S, Gramlich G, Hartmann M, Lederman K, Luckner-Neugebauer J, Pavicic T, Stangl S, Walker T, Zenker S, Wolters M (2010) Expert guideline on the use of porcine collagen in aesthetic medicine. J Dtsch Dermatol Ges 8:210–217PubMedCrossRefGoogle Scholar
  77. Rzany B, Bayerl C, Bodokh I, Boineau D, Dirschka T, Queille-Roussel C, Sebastian M, Sommer B, Poncet M, Guennoun M, Podda M (2011) Efficacy and safety of a new hyaluronic acid dermal filler in the treatment of moderate nasolabial folds: 6-month interim results of a randomized, evaluator-blinded, intra-individual comparison study. J Cosmet Laser Ther 13:107–112PubMedCrossRefGoogle Scholar
  78. Rzany B, Cartier H, Kestemont P, Trevidic P, Sattler G, Kerrouche N, Dhuin JC, Ma YM (2012) Full-face rejuvenation using a range of hyaluronic acid fillers: efficacy, safety, and patient satisfaction over 6 months. Dermatol Surg 38(7 Pt 2):1153–1161PubMedCrossRefGoogle Scholar
  79. Sadick NS, Palmisano L (2009) Cheek augmentation with Dermicol-P35 27G. Aesthet Surg J 29:S5–S8PubMedCrossRefGoogle Scholar
  80. Saray A (2003) Porcine dermal collagen (Permacol) for facial contour augmentation: preliminary report. Aesthetic Plast Surg 27(5):368–375PubMedCrossRefGoogle Scholar
  81. Schelke LW, van den Elzen HJ, Canninga M, Neumann MH (2009) Complications after treatment with polyalkylimide. Dermatol Surg 35(Suppl 2):1625–1628PubMedCrossRefGoogle Scholar
  82. Schierle CF, Casas LA (2011) Nonsurgical rejuvenation of the aging face with injectable poly-L-lactic acid for restoration of soft tissue volume. Aesthet Surg J 31(1):95–109PubMedCrossRefGoogle Scholar
  83. Schuller-Petrović S, Pavlović MD, Schuller SS, Schuller-Lukić B, Neuhold N (2013) Early granulomatous foreign body reactions to a novel alginate dermal filler: the system’s failure? J Eur Acad Dermatol Venereol 27(1):121–123PubMedCrossRefGoogle Scholar
  84. Sclafani AP et al (2000) Autologous collagen dispersion (Autologen) as a dermal filler: clinical observations and histologic findings. Arch Facial Plast Surg 2(1):48–52PubMedCrossRefGoogle Scholar
  85. Sclafani AP et al (2002a) Rejuvenation of the aging lip with an injectable acellular dermal graft (Cymetra). Arch Facial Plast Surg 4(4):252–257PubMedCrossRefGoogle Scholar
  86. Sclafani AP et al (2002b) Homologous collagen dispersion (dermalogen) as a dermal filler: persistence and histology compared with bovine collagen. Ann Plast Surg 49(2):181–188PubMedCrossRefGoogle Scholar
  87. Shafir R et al (2000) Long-term complications of facial injections with Restylane (injectable hyaluronic acid). Plast Reconstr Surg 106(5):1215–1216PubMedCrossRefGoogle Scholar
  88. Shoshani D, Markovitz E, Cohen Y, Heremans A, Goldlust A (2007) Skin test hypersensitivity study of a cross-linked, porcine collagen implant for aesthetic surgery. Dermatol Surg 33(Suppl 2):S152–S158PubMedCrossRefGoogle Scholar
  89. Silvers SL, Eviatar JA, Echavez MI, Pappas AL (2006) Prospective, open-label, 18-month trial of calcium hydroxylapatite (Radiesse) for facial soft-tissue augmentation in patients with human immunodeficiency virus-associated lipoatrophy: one-year durability. Plast Reconstr Surg 118(Suppl 3):34S–45SPubMedCrossRefGoogle Scholar
  90. Sklar JA, White SM (2004) Radiance FN: a new soft tissue filler. Dermatol Surg 30(5):764–768; discussion 768PubMedCrossRefGoogle Scholar
  91. Smith S, Busso M, McClaren M, Bass LS (2007) A randomized, bilateral, prospective comparison of calcium hydroxylapatite microspheres versus human-based collagen for the correction of nasolabial folds. Dermatol Surg 33(Suppl 2):S112–S121PubMedCrossRefGoogle Scholar
  92. Sperling B, Bachmann F, Hartmann V, Erdmann R, Wiest L, Rzany B (2010) The current state of treatment of adverse reactions to injectable fillers. Dermatol Surg 36(Suppl 3):1895–1904PubMedCrossRefGoogle Scholar
  93. Sung MS, Kim HG, Woo KI, Kim YD (2010) Ocular ischemia and ischemic oculomotor nerve palsy after vascular embolization of injectable calcium hydroxylapatite filler. Ophthal Plast Reconstr Surg 26(4):289–291PubMedCrossRefGoogle Scholar
  94. Tzikas TL (2004) Evaluation of the Radiance FN soft tissue filler for facial soft tissue augmentation. Arch Facial Plast Surg 6(4):234–239PubMedCrossRefGoogle Scholar
  95. Valantin MA et al (2003) Polylactic acid implants (New-Fill®) to correct facial lipoatrophy in HIV-infected patients: results of the open-label study VEGA. AIDS 17(17):2471–2477PubMedCrossRefGoogle Scholar
  96. Wang YB et al (2003) Clinically analyzing the possible side-effects after injecting hydrophilic poly-acrylamide gel as a soft-tissue filler. Zhonghua Zheng Xing Wai Ke Za Zhi 19(5):328–330PubMedGoogle Scholar
  97. Waris E (2003) Alloplastic injectable biomaterials for soft tissue augmentation: a report on two cases with complications associated with a new material (Dermalive) and a review of the literature. Eur J Plast Surg 26:350–355Google Scholar
  98. Webster RC et al (1986) Injectable silicone for facial soft-tissue augmentation. Arch Otolaryngol Head Neck Surg 112(3):290–296PubMedCrossRefGoogle Scholar
  99. Woerle B et al (2004) Poly-L-lactic acid: a temporary filler for soft tissue augmentation. J Drugs Dermatol 3(4):385–389PubMedGoogle Scholar
  100. Zielke H, Wölber L, Wiest L, Rzany B (2008) Risk profiles of different injectable fillers: results from the Injectable Filler Safety Study (IFS Study). Dermatol Surg 34(3):326–335; discussion 335PubMedCrossRefGoogle Scholar

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© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  • Berthold Rzany
    • 1
  1. 1.RZANY & HUND Privatpraxis für Dermatologie und Ästhetische MedizinBerlinGermany

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