Neurotrophins in the Regulation of Cellular Survival and Death

  • Claire Ceni
  • Nicolas Unsain
  • Michele P. Zeinieh
  • Philip A. Barker
Part of the Handbook of Experimental Pharmacology book series (HEP, volume 220)


The neurotrophins play crucial roles regulating survival and apoptosis in the developing and injured nervous system. The four neurotrophins exert profound and crucial survival effects on developing peripheral neurons, and their expression and action is intimately tied to successful innervation of peripheral targets. In the central nervous system, they are dispensable for neuronal survival during development but support neuronal survival after lesion or other forms of injury. Neurotrophins also regulate apoptosis of both peripheral and central neurons, and we now recognize that there are regulatory advantages to having the same molecules regulate life and death decisions. This chapter examines the biological contexts in which these events take place and highlights the specific ligands, receptors, and signaling mechanisms that allow them to occur.


Proneurotrophins p75NTR Sortilin Retrograde signaling Tumor cells Apoptosis Death domains NF-kB Interleukin-1 receptor associated kinase (IRAK) RIP2 Receptor-interacting serine/Threonine-protein kinase 2 (RIP2) Neurotrophin receptor interacting factor (NRIF) Neurotrophin receptor-interacting MAGE homolog (NRAGE) 


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Copyright information

© Springer-Verlag Berlin Heidelberg 2014 2014

Authors and Affiliations

  • Claire Ceni
    • 1
  • Nicolas Unsain
    • 1
  • Michele P. Zeinieh
    • 1
  • Philip A. Barker
    • 1
  1. 1.Centre for Neuronal SurvivalMontreal Neurological Institute, McGill UniversityMontrealCanada

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