Sortilins in Neurotrophic Factor Signaling

Chapter
First Online:
Part of the Handbook of Experimental Pharmacology book series (HEP, volume 220)

Abstract

The sortilin family of Vps10p-domain receptors includes sortilin, SorLA, and SorCS1–3. These type-I transmembrane receptors predominate in distinct neuronal tissues, but expression is also present in certain specialized non-neuronal cell populations including hepatocytes and cells of the immune system. The biology of sortilins is complex as they participate in both cell signaling and in intracellular protein sorting. Sortilins function physiologically in signaling by pro- and mature neurotrophins in neuronal viability and functionality. Recent genome-wide association studies have linked members to neurological disorders such as Alzheimer’s disease and bipolar disorder and outside the nervous system to development of coronary artery disease and type-2 diabetes. Particularly well described are the receptor functions in neuronal signaling by pro- (proNT) and mature (NT) neurotrophins and in the processing/metabolism of amyloid precursor protein (APP).

Keywords

Vps10p-domain receptors Proneurotrophins p75NTR SorCS1 SorCS2 SorCS3 Alzheimer’s disease Bipolar disorder Cell death Amyloid precursor protein Protein sorting Apoptosis 
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Copyright information

© Springer-Verlag Berlin Heidelberg 2014 2014

Authors and Affiliations

  1. 1.Danish Research Institute of Translational Neuroscience DANDRITE, Nordic EMBL Partnership, and The Lundbeck Foundation Research Center MIND, Department of BiomedicineUniversity of AarhusAarhus CDenmark

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