SVM Analysis of Haemophilia A by Using Protein Structure

  • Kenji Aoki
  • Kunihito Yamamori
  • Makoto Sakamoto
  • Hiroshi Furutani
Part of the Lecture Notes in Computer Science book series (LNCS, volume 8227)


Haemophilia A is a genetic disease resulting from deficiency of factor VIII. The database of mutations causing haemophilia A has been developed by the world wide collaboration. In this study, we examined the relation between activity of factor VIII and the missense mutation by using Support Vector Machine (SVM). As parameters, we used four physical-chemical parameters of amino acids and a structural feature. As a result, we predicted the severity of haemophilia A by using SVM in A domains of factor VIII. The structural parameters influence the prediction in A domains.


Haemophilia A Factor VIII Amino Acid Support Vector Machine 


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Copyright information

© Springer-Verlag Berlin Heidelberg 2013

Authors and Affiliations

  • Kenji Aoki
    • 1
  • Kunihito Yamamori
    • 2
  • Makoto Sakamoto
    • 2
  • Hiroshi Furutani
    • 2
  1. 1.Information Technology CenterUniversity of MiyazakiMiyazaki CityJapan
  2. 2.Faculty of EngineeringUniversity of MiyazakiMiyazaki CityJapan

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