Maximum Entropy Production and Maximum Shannon Entropy as Germane Principles for the Evolution of Enzyme Kinetics

  • Andrej DobovišekEmail author
  • Paško Županović
  • Milan Brumen
  • Davor Juretić
Part of the Understanding Complex Systems book series (UCS)


There have been many attempts to use optimization approaches to study the biological evolution of enzyme kinetics. Our basic assumption here is that the biological evolution of catalytic cycle fluxes between enzyme internal functional states is accompanied by increased entropy production of the fluxes and increased Shannon information entropy of the states. We use simplified models of enzyme catalytic cycles and bioenergetically important free-energy transduction cycles to examine the extent to which this assumption agrees with experimental data. We also discuss the relevance of Prigogine’s minimal entropy production theorem to biological evolution.


Entropy Production Metabolic Flux Forward Rate Proton Motive Force Thermodynamic Force 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  • Andrej Dobovišek
    • 1
    Email author
  • Paško Županović
    • 2
  • Milan Brumen
    • 1
    • 3
  • Davor Juretić
    • 2
  1. 1.Natural Sciences and Mathematics, Medicine, and Health SciencesUniversity of MariborMariborSlovenia
  2. 2.Department of Physics, Faculty of ScienceUniversity of SplitSplitCroatia
  3. 3.Jožef Stefan InstituteLjubljanaSlovenia

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