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Under-Approximating Cut Sets for Reachability in Large Scale Automata Networks

  • Loïc Paulevé
  • Geoffroy Andrieux
  • Heinz Koeppl
Part of the Lecture Notes in Computer Science book series (LNCS, volume 8044)

Abstract

In the scope of discrete finite-state models of interacting components, we present a novel algorithm for identifying sets of local states of components whose activity is necessary for the reachability of a given local state. If all the local states from such a set are disabled in the model, the concerned reachability is impossible.

Those sets are referred to as cut sets and are computed from a particular abstract causality structure, so-called Graph of Local Causality, inspired from previous work and generalised here to finite automata networks. The extracted sets of local states form an under-approximation of the complete minimal cut sets of the dynamics: there may exist smaller or additional cut sets for the given reachability.

Applied to qualitative models of biological systems, such cut sets provide potential therapeutic targets that are proven to prevent molecules of interest to become active, up to the correctness of the model. Our new method makes tractable the formal analysis of very large scale networks, as illustrated by the computation of cut sets within a Boolean model of biological pathways interactions gathering more than 9000 components.

Keywords

Local State Global State Boolean Network Fault Tree Boolean Model 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2013

Authors and Affiliations

  • Loïc Paulevé
    • 1
  • Geoffroy Andrieux
    • 2
  • Heinz Koeppl
    • 1
    • 3
  1. 1.ETH ZürichSwitzerland
  2. 2.IRISA RennesFrance
  3. 3.IBM Research - ZurichRueschlikonSwitzerland

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