Thalamo-Cortical Network and Seizure Dynamics: A Computational Study

  • F. Vallone
  • S. Chillemi
  • M. Barbi
  • A. Di Garbo
Part of the Lecture Notes in Computer Science book series (LNCS, volume 7930)


Experimental data indicate that thalamic inputs are important factors for the generation and termination of seizures. In this paper a minimal biophysical model of cortico-thalamo-cortical network is investigated by a computational approach. The results show that a change in the amplitude of synaptic currents between thalamic and cortical neurons promotes seizure like dynamics. Moreover, the increase of the level of inhibition between neurons of the thalamic network is sufficient for seizure termination.


Pyramidal Neuron Pyramidal Cell Spike Activity Excitatory Input Seizure Termination 
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Copyright information

© Springer-Verlag Berlin Heidelberg 2013

Authors and Affiliations

  • F. Vallone
    • 1
  • S. Chillemi
    • 1
  • M. Barbi
    • 1
  • A. Di Garbo
    • 1
  1. 1.Sezione di PisaIstituto di Biofisica CNRPisaItaly

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