JAK-STAT Signalling as Example for a Database-Supported Modular Modelling Concept
We present a detailed model of the JAK-STAT pathway in IL-6 signaling as non-trivial case study demonstrating a new database-supported modular modeling method. A module is a self-contained and autonomous Petri net, centred around an individual protein. The modelling approach allows to easily generate and modify coherent, executable models composed from a collection of modules and provides numerous options for advanced biomodel engineering.
KeywordsCoarse Transition Executable Model Numerous Option Degradation Module Biomolecular Network
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