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Pathology Hinting as the Combination of Automatic Segmentation with a Statistical Shape Model

  • Pascal A. Dufour
  • Hannan Abdillahi
  • Lala Ceklic
  • Ute Wolf-Schnurrbusch
  • Jens Kowal
Part of the Lecture Notes in Computer Science book series (LNCS, volume 7512)

Abstract

With improvements in acquisition speed and quality, the amount of medical image data to be screened by clinicians is starting to become challenging in the daily clinical practice. To quickly visualize and find abnormalities in medical images, we propose a new method combining segmentation algorithms with statistical shape models. A statistical shape model built from a healthy population will have a close fit in healthy regions. The model will however not fit to morphological abnormalities often present in the areas of pathologies. Using the residual fitting error of the statistical shape model, pathologies can be visualized very quickly. This idea is applied to finding drusen in the retinal pigment epithelium (RPE) of optical coherence tomography (OCT) volumes. A segmentation technique able to accurately segment drusen in patients with age-related macular degeneration (AMD) is applied. The segmentation is then analyzed with a statistical shape model to visualize potentially pathological areas. An extensive evaluation is performed to validate the segmentation algorithm, as well as the quality and sensitivity of the hinting system. Most of the drusen with a height of 85.5 μm were detected, and all drusen at least 93.6 μm high were detected.

Keywords

pathology hinting statistical shape model multi-surface segmentation optical coherence tomography 

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Copyright information

© Springer-Verlag Berlin Heidelberg 2012

Authors and Affiliations

  • Pascal A. Dufour
    • 1
    • 2
  • Hannan Abdillahi
    • 3
  • Lala Ceklic
    • 3
  • Ute Wolf-Schnurrbusch
    • 2
    • 3
  • Jens Kowal
    • 1
    • 2
  1. 1.ARTORG Center for Biomedical Engineering Research, Ophthalmic TechnologiesUniversity of BernBernSwitzerland
  2. 2.Ophthalmic DepartmentUniversity Hospital BernBernSwitzerland
  3. 3.Bern Photographic Reading CenterBernSwitzerland

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