Similarity-Based Appearance-Prior for Fitting a Subdivision Mesh in Gene Expression Images

  • Yen H. Le
  • Uday Kurkure
  • Nikos Paragios
  • Tao Ju
  • James P. Carson
  • Ioannis A. Kakadiaris
Part of the Lecture Notes in Computer Science book series (LNCS, volume 7510)


Automated segmentation of multi-part anatomical objects in images is a challenging task. In this paper, we propose a similarity-based appearance-prior to fit a compartmental geometric atlas of the mouse brain in gene expression images. A subdivision mesh which is used to model the geometry is deformed using a Markov Random Field (MRF) framework. The proposed appearance-prior is computed as a function of the similarity between local patches at corresponding atlas locations from two images. In addition, we introduce a similarity-saliency score to select the mesh points that are relevant for the computation of the proposed prior. Our method significantly improves the accuracy of the atlas fitting, especially in the regions that are influenced by the selected similarity-salient points, and outperforms the previous subdivision mesh fitting methods for gene expression images.


segmentation gene expression image subdivision mesh 


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Copyright information

© Springer-Verlag Berlin Heidelberg 2012

Authors and Affiliations

  • Yen H. Le
    • 1
  • Uday Kurkure
    • 1
  • Nikos Paragios
    • 1
    • 2
  • Tao Ju
    • 3
  • James P. Carson
    • 4
  • Ioannis A. Kakadiaris
    • 1
  1. 1.Computational Biomedicine LabUniversity of HoustonHoustonUSA
  2. 2.Center for Visual ComputingEcole Centrale de ParisFrance
  3. 3.Washington University in St. LouisUSA
  4. 4.Pacific Northwest National LaboratoryRichlandUSA

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