Stella and Zygotic Reprogramming
The development of a mouse begins after fertilization, the fusion of the ovulated oocyte with a sperm. During the development of the preimplantation embryo, the parental genomes undergo extensive epigenetic reprogramming, including genome-wide DNA demethylation. Shortly after fertilization, DNA methylation of the paternal genome is rapidly removed by a replication-independent process. In contrast, DNA methylation of the maternal genome is reduced gradually, in a replication-dependent manner. Thus, DNA methylation status is quite different between the paternal and maternal genomes in the zygote stage; this difference is called “epigenetic asymmetry.” Recent studies have revealed that the maternal factor Stella (also known as PGC7 and Dppa3, “developmental pluripotency-associated 3”) is required for both the maintenance of DNA methylation status of some imprinted genes and retrotransposons and for the establishment of epigenetic asymmetry in zygotes.
- Zuo X, Sheng J, Lau HT et al (2012) Zinc finger protein ZFP57 requires its co-factor to recruit DNA methyltransferases and maintains DNA methylation imprint in embryonic stem cells via its transcriptional repression domain. J Biol Chem 287:2107–2118. doi:10.1074/jbc.M111.322644 PubMedCentralPubMedCrossRefGoogle Scholar