Quantification of Tc-99m Sestamibi Distribution in Normal Breast Tissue Using Dedicated Breast SPECT-CT

  • Steve D. Mann
  • Kristy L. Perez
  • Emily K. E. McCracken
  • Jainil P. Shah
  • Kingshuk R. Choudhury
  • Terence Z. Wong
  • Martin P. Tornai
Part of the Lecture Notes in Computer Science book series (LNCS, volume 7361)

Abstract

The use of Tc-99m-Sestamibi in molecular breast imaging is common due to its preferential uptake in malignant tissue. However, quantification of the baseline uptake in normal, healthy breast tissue is not possible using planar-imaging devices. Using our dedicated breast SPECT-CT system, an IRB approved pilot study is underway to quantify mean activity in normal breast tissue, and to differentiate uptake between adipose and glandular tissues. A cohort of patients at normal breast cancer risk undergoing another diagnostic Sestamibi study was imaged using the breast SPECT-CT system. SPECT images were corrected and quantitatively reconstructed using previously developed methods, and registered with the CT images. The CT images were segmented, and the average activity concentration was measured for glandular, adipose, and total breast tissue. Results indicate no preferential uptake between tissues and low average uptake, which may be used to determine a universal threshold for cancer detection.

Keywords

breast cancer breast imaging quantification SPECT CT Sestamibi 

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References

  1. 1.
    O’Connor, M., Rhodes, D., Hruska, C.: Molecular breast imaging. Expert Rev. Anticancer Ther. 9, 1073–1080 (2009)CrossRefGoogle Scholar
  2. 2.
    Khalkhali, I., et al.: Technetium-99m-Sestamibi Scintimammography of Breast Lesions: Clinical and Pathological Follow-up. J. Nucl. Med. 36, 1784–1789 (1994)Google Scholar
  3. 3.
    Rosenthal, M.S., et al.: Quantitative SPECT imaging: a review and recommendations by the Focus Committee of the Society of Nuclear Medicine Computer and Instrumentation Council. J. Nucl. Med. 36, 1489–1513 (1995)Google Scholar
  4. 4.
    Hruska, C.B., O’Conner, M.K.: Quantification of Lesion Size, Depth and Uptake Using a Dual-Head Molecular Breast Imaging System. Med. Phys. 35, 1365–1376 (2008)CrossRefGoogle Scholar
  5. 5.
    Brem, R.F., et al.: Breast-specific gamma imaging as an adjunct imaging modality for the diagnosis of breast cancer. Radiology 247, 651–657 (2008)CrossRefGoogle Scholar
  6. 6.
    Perez, K.L., Cutler, S.J., Madhav, P., Tornai, M.P.: Towards Quantification of Dedicated Breast SPECT Using Non-Traditional Acquisition Trajectories. IEEE Trans. Nucl. Sci. 58, 2219–2225 (2011)CrossRefGoogle Scholar
  7. 7.
    Maublant, J., et al.: Technetium-99m-Sestamibi Uptake in Breast Tumor and Associated Lymph Nodes. J. Nucl. Med. 37(6), 922–925 (1996)Google Scholar
  8. 8.
    Madhav, P., Crotty, D.J., McKinley, R.L., Tornai, M.P.: Evaluation of Tilted Cone-Beam CT Orbits in the Development of a Dedicated Hybrid Mammotomograph. Phys. Med. Biol. 54, 3659–3676 (2009)CrossRefGoogle Scholar
  9. 9.
    Madhav, P., et al. In: vivo characterization of breast tissues through absolute attenuation coefficients using dedicated cone-beam CT. In: Proc. SPIE 7622, 762209 (2010)Google Scholar
  10. 10.
    Crotty, D.J., et al.: Evaluation of the Absorbed Dose to the Breast Using Radiochromic Film in a Dedicated CT Mammotomography System Employing a Quasi-Monchromatic Beam. Med. Phys. 38(6), 3232–3245 (2011)CrossRefGoogle Scholar
  11. 11.
    McKinley, R.L., et al.: Initial Study of a Quasi-Monochromatic Beam Performance for X-ray Computed Mammotomography. IEEE Trans. Nucl. Sci. NS-52(5), 1243–1250 (2005)Google Scholar
  12. 12.
    Brzymialkiewicz, C.N., et al.: Evaluation of Fully 3D Emission Mammotomography with a Compact Cadmium Zinc Telluride Detector. IEEE Trans. Med. Imag. MI-24(7), 868–877 (2005)Google Scholar
  13. 13.
    Jaszczak, R.J., et al.: Improved SPECT Quantification Using Compensation for Scattered Photons. J. Nucl. Med. 25, 893–900 (1984)Google Scholar
  14. 14.
    Vranjesevic, D., et al.: Relationship Between 18F-FDG Uptake and Breast Density in Women with Normal Breast Tissue. J. Nucl. Med. 44, 1238–1242 (2003)Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2012

Authors and Affiliations

  • Steve D. Mann
    • 1
  • Kristy L. Perez
    • 2
  • Emily K. E. McCracken
    • 3
  • Jainil P. Shah
    • 2
  • Kingshuk R. Choudhury
    • 2
  • Terence Z. Wong
    • 2
  • Martin P. Tornai
    • 1
    • 2
    • 4
  1. 1.Medical Physics Graduate ProgramDuke UniversityDurhamUSA
  2. 2.Department of RadiologyDuke University Medical CenterDurhamUSA
  3. 3.Duke University Medical SchoolDurhamUSA
  4. 4.Department of Biomedical EngineeringDuke UniversityDurhamUSA

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