Animal Studies in Deep Brain Stimulation Research

Chapter

Abstract

The main goal of deep brain stimulation (DBS) research is to offer a better insight into the mechanism of action of DBS. In addition, it is also necessary to provide an experimental basis for new therapeutic applications, for novel targets, and for optimizing stimulation parameters in psychiatric disorders. This chapter provides a description of the essential advantages of animal research to achieve these goals. In addition, we discuss the limitations of animal research and suggest that a fruitful approach is offered by a careful selection of disease-independent neurobehavioral domains, for which translational methods are available. Two examples of such domains, anxiety and reward processing, are presented.

Keywords

Major Depressive Disorder Deep Brain Stimulation Brain Stimulation Reward Processing Medial Forebrain Bundle 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. Alvarez RP, Biggs A, Chen G, Pine DS, Grillon C (2008) Contextual fear conditioning in humans: cortical-hippocampal and amygdala contributions. J Neurosci 28:6211–6219PubMedCrossRefGoogle Scholar
  2. Aupperle RL, Paulus MP (2010) Neural systems underlying approach and avoidance in anxiety disorders. Dialogues Clin Neurosci 12:517–531PubMedGoogle Scholar
  3. Baumeister AA (2000) The Tulane electrical brain stimulation program a historical case study in medical ethics. J Hist Neurosci 9:262–278PubMedCrossRefGoogle Scholar
  4. Baunez C (2011) A few examples of the contribution of animal research in rodents for clinical application of deep brain stimulation. Prog Brain Res 194:105–116PubMedCrossRefGoogle Scholar
  5. Bichot NP, Heard MT, Desimone R (2011) Stimulation of the nucleus accumbens as behavioral reward in awake behaving monkeys. J Neurosci Methods 199:265–272PubMedCrossRefGoogle Scholar
  6. Bishop MP, Elder ST, Heath RG (1963) Intracranial self-stimulation in man. Science 140:394–396PubMedCrossRefGoogle Scholar
  7. Carlezon WA Jr, Chartoff EH (2007) Intracranial self-stimulation (ICSS) in rodents to study the neurobiology of motivation. Nat Protoc 2:2987–2995PubMedCrossRefGoogle Scholar
  8. Chamberlain SR, Menzies L (2009) Endophenotypes of obsessive–compulsive disorder: rationale, evidence and future potential. Expert Rev Neurother 9:1133–1146PubMedCrossRefGoogle Scholar
  9. Davis M, Walker DL, Miles L, Grillon C (2010) Phasic vs sustained fear in rats and humans: role of the extended amygdala in fear vs anxiety. Neuropsychopharmacology 35:105–135PubMedCrossRefGoogle Scholar
  10. Denys D, Mantione M, Figee M, van den Munckhof P, Koerselman F, Westenberg H, Bosch A, Schuurman R (2010) Deep brain stimulation of the nucleus accumbens for treatment-refractory obsessive-compulsive disorder. Arch Gen Psychiatry 67:1061–1068PubMedCrossRefGoogle Scholar
  11. Fernando AB, Robbins TW (2011) Animal models of neuropsychiatric disorders. Annu Rev Clin Psychol 7:39–61PubMedCrossRefGoogle Scholar
  12. Figee M, Vink M, de Geus F, Vulink N, Veltman DJ, Westenberg H, Denys D (2011) Dysfunctional reward circuitry in obsessive-compulsive disorder. Biol Psychiatry 69:867–874PubMedCrossRefGoogle Scholar
  13. Gould TD, Gottesman II (2006) Psychiatric endophenotypes and the development of valid animal models. Genes Brain Behav 5:113–119PubMedCrossRefGoogle Scholar
  14. Gottesman II, Gould TD (2003) The endophenotype concept in psychiatry: etymology and strategic intentions. Am J Psychiatry 160:636–645PubMedCrossRefGoogle Scholar
  15. Gubellini P, Salin P, Kerkerian-Le Goff L, Baunez C (2009) Deep brain stimulation in neurological diseases and experimental models: from molecule to complex behavior. Prog Neurobiol 89:79–123Google Scholar
  16. Hariz MI, Blomstedt P, Zrinzo L (2010) Deep brain stimulation between 1947 and 1987: the untold story. Neurosurg Focus 29:E1PubMedCrossRefGoogle Scholar
  17. Heath RG (1963) Electrical self-stimulation of the brain in man. Am J Psychiatry 120:571–577PubMedGoogle Scholar
  18. Hernandez G, Hamdani S, Rajabi H, Conover K, Stewart J, Arvanitogiannis A, Shizgal P (2006) Prolonged rewarding stimulation of the rat medial forebrain bundle: neurochemical and behavioral consequences. Behav Neurosci 120:888–904PubMedCrossRefGoogle Scholar
  19. Kellendonk C, Simpson EH, Kandel ER (2009) Modeling cognitive endophenotypes of schizophrenia in mice. Trends Neurosci 32:347–358PubMedCrossRefGoogle Scholar
  20. Kornetsky C, Bain G (1992) Brain-stimulation reward: a model for the study of the rewarding effects of abused drugs. NIDA Res Monogr 124:73–93PubMedGoogle Scholar
  21. Luyten L, Vansteenwegen D, van Kuyck K, Gabriëls L, Nuttin B (2011) Contextual conditioning in rats as an animal model for generalized anxiety disorder. Cogn Affect Behav Neurosci 11:228–244PubMedCrossRefGoogle Scholar
  22. Millan MJ (2003) The neurobiology and control of anxious states. Prog Neurobiol 70:83–244PubMedCrossRefGoogle Scholar
  23. Milner PM (1991) Brain-stimulation reward: a review. Can J Psychol 45:1–36PubMedCrossRefGoogle Scholar
  24. Nestler EJ, Hyman SE (2010) Animal models of neuropsychiatric disorders. Nat Neurosci 13:1161–1169PubMedCrossRefGoogle Scholar
  25. Olds J (1958) Self-stimulation of the brain; its use to study local effects of hunger, sex, and drugs. Science 127:315–324PubMedCrossRefGoogle Scholar
  26. Oshima H, Katayama Y (2010) Neuroethics of deep brain stimulation for mental disorders: brain stimulation reward in humans. Neurol Med Chir (Tokyo) 50:845–852Google Scholar
  27. Pollock J, Kornetsky C (1990) Pharmacologic evidence for nociception resulting from noncontingent “rewarding” brain stimulation. Physiol Behav 47:761–765PubMedCrossRefGoogle Scholar
  28. Rodriguez-Romaguera J, Do Monte FH, Quirk GJ (2012) Deep brain stimulation of the ventral striatum enhances extinction of conditioned fear. Proc Natl Acad Sci USA 109:8764–8769Google Scholar
  29. Rokosik SL, Napier TC (2011) Intracranial self-stimulation as a positive reinforcer to study impulsivity in a probability discounting paradigm. J Neurosci Methods 198:260–269PubMedCrossRefGoogle Scholar
  30. Temel Y, Tan S, Vlamings R, Sesia T, Lim LW, Lardeux S, Visser-Vandewalle V, Baunez C (2009) Cognitive and limbic effects of deep brain stimulation in preclinical studies. Front Biosci 14:1891–1901PubMedCrossRefGoogle Scholar
  31. van Dijk A, Klanker M, Hamelink R, Feenstra M, Denys D (2012) Differential anxiolytic effects during deep brain stimulation in striatal areas and the internal capsule. FENS abstr 2630Google Scholar
  32. Witten IB, Steinberg EE, Lee SY, Davidson TJ, Zalocusky KA, Brodsky M, Yizhar O, Cho SL, Gong S, Ramakrishnan C, Stuber GD, Tye KM, Janak PH, Deisseroth K (2011) Recombinase-driver rat lines: tools, techniques, and optogenetic application to dopamine-mediated reinforcement. Neuron 72:721–733PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2012

Authors and Affiliations

  1. 1.Netherlands Institute for NeuroscienceRoyal Netherlands Academy of Arts and SciencesAmsterdamThe Netherlands
  2. 2.Department of Psychiatry, Academic Medical CenterUniversity of AmsterdamAmsterdamThe Netherlands

Personalised recommendations