Scientific Recordings in Deep Brain Stimulation
The primary purpose of deep brain stimulation (DBS) is to treat a brain disorder by applying electrical stimulation to a specific part of the brain. There is typically a small window of time during or shortly after surgical implantation of the DBS electrodes in which electrophysiological signals from the DBS target can be recorded in awake humans while they are performing a task. This allows scientific investigations into the electrophysiological functioning of brain structures that are otherwise inaccessible using noninvasive imaging techniques. Although there are some drawbacks to DBS recordings, such as concerns of generalizability to nonclinical populations, there is also great scientific potential to elucidate fundamental electrophysiological mechanisms of neural information processing and transfer, with better spatial resolution and data signal quality than typically available in humans. This chapter provides an overview of the motivation, methods, advantages, limitations, and ethical issues involved in conducting scientific recordings in deep brain regions in DBS patients.
KeywordsDeep Brain Stimulation Local Field Potential Deep Brain Stimulation Electrode Deep Brain Structure Deep Brain Stimulation Treatment
- Bronstein JM, Tagliati M, Alterman RL, Lozano AM, Volkmann J, Stefani A, Horak FB, Okun MS, Foote KD, Krack P, Pahwa R, Henderson JM, Hariz MI, Bakay RA, Rezai A, Marks WJ Jr, Moro E, Vitek JL, Weaver FM, Gross RE, DeLong MR (2010) Deep brain stimulation for Parkinson disease: an expert consensus and review of key issues. Arch Neurol 68:165PubMedCrossRefGoogle Scholar
- Cohen MX, Bour L, Mantione M, Figee M, Vink M, Tijssen MA, Rootselaar AF, Munckhof PV, Richard Schuurman P, Denys D (2012) Top–down-directed synchrony from medial frontal cortex to nucleus accumbens during reward anticipation. Hum Brain Mapp 33:246–252Google Scholar
- Tan S, Vlamings R, Lim L, Sesia T, Janssen ML, Steinbusch HW, Visser-Vandewalle V, Temel Y (2010) Experimental deep brain stimulation in animal models. Neurosurgery 67:1073–1079 (discussion 1080)Google Scholar