Scientific Recordings in Deep Brain Stimulation

Chapter

Abstract

The primary purpose of deep brain stimulation (DBS) is to treat a brain disorder by applying electrical stimulation to a specific part of the brain. There is typically a small window of time during or shortly after surgical implantation of the DBS electrodes in which electrophysiological signals from the DBS target can be recorded in awake humans while they are performing a task. This allows scientific investigations into the electrophysiological functioning of brain structures that are otherwise inaccessible using noninvasive imaging techniques. Although there are some drawbacks to DBS recordings, such as concerns of generalizability to nonclinical populations, there is also great scientific potential to elucidate fundamental electrophysiological mechanisms of neural information processing and transfer, with better spatial resolution and data signal quality than typically available in humans. This chapter provides an overview of the motivation, methods, advantages, limitations, and ethical issues involved in conducting scientific recordings in deep brain regions in DBS patients.

Keywords

Deep Brain Stimulation Local Field Potential Deep Brain Stimulation Electrode Deep Brain Structure Deep Brain Stimulation Treatment 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. Bronstein JM, Tagliati M, Alterman RL, Lozano AM, Volkmann J, Stefani A, Horak FB, Okun MS, Foote KD, Krack P, Pahwa R, Henderson JM, Hariz MI, Bakay RA, Rezai A, Marks WJ Jr, Moro E, Vitek JL, Weaver FM, Gross RE, DeLong MR (2010) Deep brain stimulation for Parkinson disease: an expert consensus and review of key issues. Arch Neurol 68:165PubMedCrossRefGoogle Scholar
  2. Canolty RT, Knight RT (2010) The functional role of cross-frequency coupling. Trends Cogn Sci 14:506–515PubMedCrossRefGoogle Scholar
  3. Cohen MX, Axmacher N, Lenartz D, Elger CE, Sturm V, Schlaepfer TE (2009a) Nuclei accumbens phase synchrony predicts decision-making reversals following negative feedback. J Neurosci 29:7591–7598PubMedCrossRefGoogle Scholar
  4. Cohen MX, Axmacher N, Lenartz D, Elger CE, Sturm V, Schlaepfer TE (2009b) Good vibrations: cross-frequency coupling in the human nucleus accumbens during reward processing. J Cogn Neurosci 21:875–889PubMedCrossRefGoogle Scholar
  5. Cohen MX, Bour L, Mantione M, Figee M, Vink M, Tijssen MA, Rootselaar AF, Munckhof PV, Richard Schuurman P, Denys D (2012) Top–down-directed synchrony from medial frontal cortex to nucleus accumbens during reward anticipation. Hum Brain Mapp 33:246–252Google Scholar
  6. de Koning PP, Figee M, van den Munckhof P, Schuurman PR, Denys D (2011) Current status of deep brain stimulation for obsessive-compulsive disorder: a clinical review of different targets. Curr Psychiatry Rep 13:274–282PubMedCrossRefGoogle Scholar
  7. Flora ED, Perera CL, Cameron AL, Maddern GJ (2010) Deep brain stimulation for essential tremor: a systematic review. Mov Disord 25:1550–1559PubMedCrossRefGoogle Scholar
  8. Hariz MI, Robertson MM (2010) Gilles de la Tourette syndrome and deep brain stimulation. Eur J Neurosci 32:1128–1134PubMedCrossRefGoogle Scholar
  9. Lisman J (2005) The theta/gamma discrete phase code occurring during the hippocampal phase precession may be a more general brain coding scheme. Hippocampus 15:913–922PubMedCrossRefGoogle Scholar
  10. Mayberg HS, Lozano AM, Voon V, McNeely HE, Seminowicz D, Hamani C, Schwalb JM, Kennedy SH (2005) Deep brain stimulation for treatment-resistant depression. Neuron 45:651–660PubMedCrossRefGoogle Scholar
  11. McCracken CB, Grace AA (2007) High-frequency deep brain stimulation of the nucleus accumbens region suppresses neuronal activity and selectively modulates afferent drive in rat orbitofrontal cortex in vivo. J Neurosci 27:12601–12610PubMedCrossRefGoogle Scholar
  12. McCracken CB, Grace AA (2009) Nucleus accumbens deep brain stimulation produces region-specific alterations in local field potential oscillations and evoked responses in vivo. J Neurosci 29:5354–5363PubMedCrossRefGoogle Scholar
  13. McIntyre CC, Hahn PJ (2010) Network perspectives on the mechanisms of deep brain stimulation. Neurobiol Dis 38:329–337PubMedCrossRefGoogle Scholar
  14. Mian MK, Campos M, Sheth SA, Eskandar EN (2010) Deep brain stimulation for obsessive-compulsive disorder: past, present, and future. Neurosurg Focus 29:E10PubMedCrossRefGoogle Scholar
  15. Schlaepfer TE, Cohen MX, Frick C, Kosel M, Brodesser D, Axmacher N, Joe AY, Kreft M, Lenartz D, Sturm V (2008) Deep brain stimulation to reward circuitry alleviates anhedonia in refractory major depression. Neuropsychopharmacology 33:368–377PubMedCrossRefGoogle Scholar
  16. Tan S, Vlamings R, Lim L, Sesia T, Janssen ML, Steinbusch HW, Visser-Vandewalle V, Temel Y (2010) Experimental deep brain stimulation in animal models. Neurosurgery 67:1073–1079 (discussion 1080)Google Scholar
  17. Zaghloul KA, Blanco JA, Weidemann CT, McGill K, Jaggi JL, Baltuch GH, Kahana MJ (2009) Human substantia nigra neurons encode unexpected financial rewards. Science 323:1496–1499PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2012

Authors and Affiliations

  1. 1.Department of PsychologyUniversity of AmsterdamAmsterdamThe Netherland
  2. 2.Department of PhysiologyUniversity of ArizonaTucsonUSA

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