Evolution of Genome Organization by Duplication and Loss: An Alignment Approach

  • Patrick Holloway
  • Krister Swenson
  • David Ardell
  • Nadia El-Mabrouk
Part of the Lecture Notes in Computer Science book series (LNCS, volume 7262)

Abstract

We present a comparative genomics approach for inferring ancestral genome organization and evolutionary scenarios, based on a model accounting for content-modifying operations. More precisely, we focus on comparing two ordered gene sequences with duplicated genes that have evolved from a common ancestor through duplications and losses; our model can be grouped in the class of “Block Edit” models. From a combinatorial point of view, the main consequence is the possibility of formulating the problem as an alignment problem. On the other hand, in contrast to symmetrical metrics such as the inversion distance, duplications and losses are asymmetrical operations that are applicable to one of the two aligned sequences. Consequently, an ancestral genome can directly be inferred from a duplication-loss scenario attached to a given alignment. Although alignments are a priori simpler to handle than rearrangements, we show that a direct approach based on dynamic programming leads, at best, to an efficient heuristic. We present an exact pseudo-boolean linear programming algorithm to search for the optimal alignment along with an optimal scenario of duplications and losses. Although exponential in the worst case, we show low running times on real datasets as well as synthetic data. We apply our algorithm in a phylogenetic context to the evolution of stable RNA (tRNA and rRNA) gene content and organization in Bacillus genomes. Our results lead to various biological insights, such as rates of ribosomal RNA proliferation among lineages, their role in altering tRNA gene content, and evidence of tRNA class conversion.

Keywords

Comparative Genomics Gene order Duplication Loss Linear Programming Alignment Bacillus tRNA 

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Copyright information

© Springer-Verlag Berlin Heidelberg 2012

Authors and Affiliations

  • Patrick Holloway
    • 1
  • Krister Swenson
    • 2
    • 3
  • David Ardell
    • 4
  • Nadia El-Mabrouk
    • 2
  1. 1.Département d’Informatique et de Recherche Opérationnelle (DIRO)Université de MontréalCanada
  2. 2.DIROCanada
  3. 3.University of McGill Computer ScienceCanada
  4. 4.Center for Computational Biology, School of Natural SciencesUniversity of CaliforniaMercedUSA

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