Evaluation on the Feasibility and Safety of Magnetic Stent Hyperthermia for Esophageal Cancer

Abstract

Magnetic mediated hyperthermia combined with endoscopic placement of a metal stent, which can be termed as magnetic stent hyperthermia (MSH), is a novel locoregional thermotherapy for esophageal cancer. Based on the strategy of MSH, inductive heat can be generated by the esophageal stent upon exposure under an alternative magnetic field (AMF) and therefore the targeted thermotherapy for esophageal cancer can be achieved. In the current work, we conducted systematic research on the feasibility and safety evaluation on the MSH for esophageal cancer. Two types of super-elastic nitinol stents provided by Beijing Institute of Nonferrous Metals, (Beijing, China) were adopted in the study. A commercially available esophageal stent in clinical application with a length of 110mm and a macroscopic diameter of 15mm (type I) was applied to study the heating inductive heating property and the temperature increase within pig’s esophagus.Both in vitro and in vivo investigation has been carried out. Our results suggest that MSH may have clinical significance for esophageal cancer treatment.