Magnetic Arterial Embolization Hyperthermia Mediated by Carbonyl Iron Powder for Liver Carcinoma

Abstract

Introduction: Magnetic arterial embolizaiton hyperthermia(MAEH) is a novel and very promising localized modality by combining the advantages of magnetic mediated hyperthermia (MMH) and transcatheter arterial embolizaiton (TAE) for liver carcinoma. This study was carried out to investigate the feasibility of carbonyl iron powder (CIP) microparticles as mediators for MAEH. The protocol was approved by institutional animal care and use committee (IACUC) of Tsinghua University. Materials and Methods: CIP microparticles were adopted in the current study. Magnetic property of the CIP was analyzed by the vibrating sample magnetometer (VSM) and inductive heating property was conducted by exposing CIP/Lipiodol suspensions under alternative magnetic field (AMF). In vivo compatibility investigation was performed on Wistar rats by i.v. injection of CIP extracts. VX2 carcinoma-induced rabbit liver tumor models were employed to study the anti-tumor effect of MAEH mediated by CIP/Lipiodol suspensions. Results and Conclusions: CIP demonstrates very good in vivo biocompatibility and ideal inductive heating characteristics under AMF. MAEH mediated by CIP is a safe and effective treatment that can target liver cancers through dual effects of local hyperthermia and arterial embolization. Our investigation provides feasibility study on developing novel and suitable mediator candidature for MAEH.