Informational Homeostasis for Shannon Entropy in Complex Networks of Oxidative Activity of DNA in Cells; Fractals, Stability and the Switching in Large-Scale Gene Nets for Fluorescing Neutrophils in Medical Diagnostics
We develop novel nonlinear methods in analysis of DNA fluorescence. Histograms fluorescence of peripheral blood neutrophils are formed by flow cytometry method with nanometer spatial resolution in the flow direction. Fluorescence of DNA in cellular nuclei is initiated by oxidative burst reaction. Recently we had found the empirical invariant, i.e. the common value for Shannon entropy based on frequency distributions of information for fluorescing DNA inside cells; N.E. Galich, J,WASET 69 (2010) 504-515. This invariant defines the informational homeostasis of oxidative activity of DNA for full set of chromosomes in all living cells and gives a total zero level for countdown all chromosomal correlations for different health conditions of various persons in genomics. We analyze topology, stability and switching for information entropy nets. We classified all initial arbitrary multimodal and bimodal distributions of entropy in homeostasis by averaging at transition to the stable and unstable large-scale distributions; here stability reflects health status or belonging to the certain groups of diseases. We defined three classes of statistical stability, individualities and types of fractals basing on bifurcations and deflections from varied scaling types. We noted abnormal fractal dimensions in nets of all scales for oncology in the contrast of fractal nets for inflammation diseases. Good health is characterized by nets close to ‘smallworlds” networks. These features combined with transitions switching in cellular and intercellular networks of information entropies are used for medical diagnostics.
Keywordsblood cell nets DNA oxidative activity 3D DNA correlations in cells fractals and intercellular networks
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