Clinical Trials Principles for Evaluation of Antimicrobial Drugs in Periodontal Disease Treatment
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According to the classic version of the non-specific theory in microbial aetiology of inflammatory periodontal disease, the indigenous oral bacteria in the absence of oral hygiene colonize the gingival crevice to form plaque. Inflammatory periodontal disease develops in the case of bacterial proliferation above the threshold of host resistance, caused by the combined biologic effects of the total plaque flora. All plaque bacteria are thought to have some of the various virulence factors causing gingival inflammation and periodontal destruction, and it is implied that plaque will cause disease regardless of its composition. Therefore, total plaque control is considered necessary in treatment and prevention, and this approach has certainly proved effective, where it can be carried out.
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