The Effective Calcium/Calmodulin Concentration Determines the Sensitivity of CaMKII to the Frequency of Calcium Oscillations

  • Thiago M. Pinto
  • Maria J. Schilstra
  • Volker Steuber
Conference paper
Part of the Lecture Notes in Computer Science book series (LNCS, volume 7223)

Abstract

Calcium/calmodulin-dependent protein kinase II (CaMKII) is involved in the induction of many forms of synaptic plasticity in the brain. Experimental and computational studies have shown that CaMKII is sensitive to the frequency of oscillatory Ca2 +  signals. Here we demonstrate that in a simple, commonly used kinetic model of CaMKII phosphorylation, the overall phosphorylation rate under sustained application of Ca4 − CaM pulses ultimately depends on the average (‘effective’) concentration of Ca4 − CaM in the system, rather than on the pulse frequency itself. As a corollary, equal phosphorylation levels are achieved in response to pulsed and constant applications of equal effective concentrations of Ca4 − CaM.

Keywords

CaMKII calmodulin Ca2 +  oscillations 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Hanson, P., Schulman, H.: Neuronal Ca2+/calmodulin-dependent protein kinases. Annual Review of Biochemistry 61(1), 559–601 (1992)CrossRefGoogle Scholar
  2. 2.
    Hanson, P., Meyer, T., Stryer, L., Schulman, H.: Dual role of calmodulin in autophosphorylation of multifunctional CaM kinase may underlie decoding of calcium signals. Neuron 12(5), 943–956 (1994)CrossRefGoogle Scholar
  3. 3.
    Michelson, S., Schulman, H.: CaM kinase: A model for its activation and dynamics. Journal of Theoretical Biology 171, 281–290 (1994)CrossRefGoogle Scholar
  4. 4.
    Dosemeci, A., Albers, R.: A mechanism for synaptic frequency detection through autophosphorylation of CaM kinase II. Biophysical Journal 70(6), 2493–2501 (1996)CrossRefGoogle Scholar
  5. 5.
    Dupont, G., Houart, G., De Koninck, P.: Sensitivity of CaM kinase II to the frequency of Ca2+ oscillations: a simple model. Cell Calcium 34(6), 485–497 (2003)CrossRefGoogle Scholar
  6. 6.
    De Koninck, P., Schulman, H.: Sensitivity of CaM kinase II to the frequency of Ca2+ oscillations. Science 279(5348), 227–230 (1998)CrossRefGoogle Scholar
  7. 7.
    Waxham, M., Putkey, J., Tsai, A.: A mechanism for calmodulin (CaM) trapping by CaM-kinase II defined by a family of CaM-binding peptides. Journal of Biological Chemistry 273(28), 17579–17584 (1998)CrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 2012

Authors and Affiliations

  • Thiago M. Pinto
    • 1
  • Maria J. Schilstra
    • 1
  • Volker Steuber
    • 1
  1. 1.Science and Technology Research InstituteUniversity of HertfordshireHatfieldUK

Personalised recommendations