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Deep Brain Stimulation as a Therapy for Alcohol Addiction

  • Thomas F. MünteEmail author
  • Hans-Jochen Heinze
  • Veerle Visser-Vandewalle
Chapter
Part of the Current Topics in Behavioral Neurosciences book series (CTBN, volume 13)

Abstract

Deep brain stimulation (DBS) has been firmly established as a therapy for movement disorders. Recently, evidence from case reports and small case series also suggests DBS to be effective in psychiatric disorders including addiction. Here we review the rationale of DBS in addiction and the selection of possible targets. We then consider evidence from animal models as well as human case studies. We conclude that DBS in particular of the nucleus accumbens (NAcc) represents a promising treatment option in addiction which deserves further investigation.

Keywords

Deep brain stimulation Nucleus accumbens Alcohol addiction Incentive salience Reward processing 

Abbreviations

DBS

Deep brain stimulation

LFP

Local field potentials

ERP

Event-related potentials

NAcc

Nucleus accumbens

SNc

Substantia nigra pars compacta

VTA

Ventral tegmental area

Notes

Acknowledgments

TFM and HJH are supported by the DFG and BMBF.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2012

Authors and Affiliations

  • Thomas F. Münte
    • 1
    Email author
  • Hans-Jochen Heinze
    • 2
  • Veerle Visser-Vandewalle
    • 3
  1. 1.Clinic for NeurologyLübeckGermany
  2. 2.Department of NeurologyUniversity of MagdeburgMagdeburgGermany
  3. 3.School for Mental Health and Neuroscience, Maastricht Institute for Neuromodulative DevelopmentMaastricht University and Medical CentreMaastrichtThe Netherlands

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