mRNA Turnover in Trypanosomes

Chapter
Part of the Nucleic Acids and Molecular Biology book series (NUCLEIC, volume 28)

Abstract

Most kinetoplastid mRNAs are synthesised by RNA polymerase II, then trans spliced, polyadenylated, and exported from the nucleus. The polycistronic nature of kinetoplastid transcription, however, means that—with a few exceptions—the amount of mRNA is determined by post-transcriptionally. Once in the cytoplasm, the amount of mRNA is determined by the rate of mRNA degradation and the amount of protein by the rates of translation initiation, elongation, and protein turnover. In many cases, regulation of mRNA turnover has been found to play a dominant role. This review discusses the mechanisms of mRNA degradation in kinetoplastids, and how that degradation is controlled.

Keywords

mRNA Degradation Stress Granule Premature Termination Codon Procyclic Form CCCH Zinc Finger 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Acknowledgements

Work in my laboratory is supported by the Land of Baden-Württemberg and the Deutsche Forschungsgemeinschaft.

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© Springer-Verlag GmbH Berlin Heidelberg 2012

Authors and Affiliations

  1. 1.Zentrum für Molekulare Biologie ZMBHHeidelbergGermany

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