Theranostics, Gallium-68, and Other Radionuclides pp 479-485 | Cite as
PRRT as Neoadjuvant Treatment in NET
Abstract
This chapter describes the possibility of using peptide receptor radionuclide therapy (PRRT) as neoadjuvant treatment. PRRT is acknowledged to be a palliative treatment. Recently it has been reported that tumor size decrease followed by surgical intervention might be achieved in patients with neuroendocrine tumors (NETs) treated with somatostatin analogs labeled with beta emitters. Such outcome of therapy has been described in a relatively small group of patients. In those patients, the treatment enabled total or partial excision of the tumor, also with liver metastases. Reduction of tumor dimensions or total excision of the tumor corresponded with prolongation of overall survival. The discussed papers on this subject differ in details of treatment (utilization of various isotopes, total activity of the isotope, or combination with radiosensitizing chemotherapy). The chapter presents a brief review of recently published manuscripts.
Keywords
Liver Metastasis Peptide Receptor Radionuclide Therapy Pancreatic Tail Pancreatic Neuroendocrine Tumor Decrease Tumor SizeAbbreviations
- CT
Computed tomography
- Ki index
Proliferation index
- NET
Neuroendocrine tumor
- PET/CT
Positron emission tomography/computed tomography
- PNT
Pancreatic neuroendocrine tumor
- PRRT
Peptide receptor radionuclide therapy
- RECIST
Response evaluation criteria for solid tumors
- SPECT-CT
Single-photon emission computed tomography
- T1/2
Physical half-life
- 5FU
5-Fluorouracil
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