Nucleosome Remodelling and Epigenome Diversification

Chapter
Part of the Research and Perspectives in Neurosciences book series (NEUROSCIENCE)

Abstract

Nucleosome remodelling factors utilize chemical energy to disrupt histone-DNA interactions in nucleosomes. They catalyze a variety of structural changes ranging from complete nucleosome disassembly and the exchange of histone variants to the sliding of intact histone octamers along DNA. The essential involvement of some remodelling complexes in neuronal transcription programs is due to lineage-specific subunits that assure the selective targeting to neuronal promoters. In addition, nucleosome remodelers may contribute to the faithful silencing of competing transcription programs by maintaining the integrity and regularity of the nucleosomal fiber as a prerequisite for higher order chromatin organization.

Keywords

Gene Expression Program Linker Histone Histone Chaperone Postmitotic Neuron Nucleosome Remodeler 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Acknowledgments

Research on nucleosome remodelling factors CHRAC and ACF in the author’s laboratory is funded by the Deutsche Forschungsgemeinschaft (DFG).

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Copyright information

© Springer-Verlag Berlin Heidelberg 2012

Authors and Affiliations

  1. 1.Adolf-Butenandt-Institute and Center of Integrated Protein ScienceLudwig-Maximilians-UniversityMunichGermany

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