Nucleosome Remodelling and Epigenome Diversification
Nucleosome remodelling factors utilize chemical energy to disrupt histone-DNA interactions in nucleosomes. They catalyze a variety of structural changes ranging from complete nucleosome disassembly and the exchange of histone variants to the sliding of intact histone octamers along DNA. The essential involvement of some remodelling complexes in neuronal transcription programs is due to lineage-specific subunits that assure the selective targeting to neuronal promoters. In addition, nucleosome remodelers may contribute to the faithful silencing of competing transcription programs by maintaining the integrity and regularity of the nucleosomal fiber as a prerequisite for higher order chromatin organization.
KeywordsGene Expression Program Linker Histone Histone Chaperone Postmitotic Neuron Nucleosome Remodeler
Research on nucleosome remodelling factors CHRAC and ACF in the author’s laboratory is funded by the Deutsche Forschungsgemeinschaft (DFG).