Vernix Caseosa and Its Substitutes: Lipid Composition and Physicochemical Properties

Chapter

Abstract

Appropriate moisturization is essential for optimum stratum corneum (SC) function [1, 2]. Among the multiple functions of the skin affected by SC water content are desquamation and self-renewal, restoration of barrier integrity after wounding, acid mantle formation, microbial colonization, tactile discrimination, infection control, immunosurveillance, and protection against ultraviolet light and environmental irritants [3]. Operationally, “appropriate” hydration may be defined as: that amount of SC water which optimizes local SC biomechanics while facilitating terminal differentiation, programmed cell death, and orderly corneocyte incorporation into the inner SC with balanced pH-dependent desquamation of the outer SC. Overhydration can cause maceration, disruption of the intercellular lipid bilayers, degradation of desmosomes and creation of amorphous regions, corneocyte swelling, and enhanced molecular transport with increased permeability [4–6], as well as inflammation, irritation, and urticaria [7–12]. Low hydration can cause visible dryness/scaling, aberrant desquamation via reduced enzyme activity, cracking, reduced flexibility, tightness, and itching. On balance, the SC water-handling properties must be sufficiently robust to respond to local, potentially disruptive forces, for example, friction, heat, humidity, bathing, clothing, secretions, and topical product applications [13].

Keywords

Stratum Corneum Amniotic Fluid Water Vapor Transport Skin Hydration Critical Surface Tension 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2012

Authors and Affiliations

  1. 1.Skin Sciences ProgramCincinnati Children’s Hospital Medical CenterCincinnatiUSA
  2. 2.Division of Plastic Surgery, College of MedicineUniversity of CincinnatiCincinnatiUSA
  3. 3.Perinatal Institute, Cincinnati Children’s Hospital, Medical CenterCincinnatiUSA
  4. 4.Department of Pediatrics, College of MedicineUniversity of CincinnatiCincinnatiUSA

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