Transport Across Tubular Epithelia

  • Anita T. Layton
  • Aurélie Edwards
Chapter
Part of the Lecture Notes on Mathematical Modelling in the Life Sciences book series (LMML)

Abstract

The kidney regulates the composition of the final urine by modulating the reabsorption and secretion of water and solutes across the specialized epithelium of each nephron segment. This chapter begins with an overview of epithelial barriers, including their permeability properties and main classes of transporters. We then derive the conservation and flux equations that are needed to represent the dynamic exchange of water and solutes across tubular epithelia. Lastly, we describe how to formulate a complete, cell-based model of transport across renal tubules.

Keywords

Tight Junction Tubular Epithelium Paracellular Pathway Solute Flux Tubular Lumen 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  • Anita T. Layton
    • 1
  • Aurélie Edwards
    • 2
  1. 1.Department of MathematicsDuke UniversityDurhamUSA
  2. 2.Centre de Recherche des Cordeliers ERL 8228, UMRS 1138 Equipe 3ParisFrance

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