Hepatitis C Virus: From Molecular Virology to Antiviral Therapy

Volume 369 of the series Current Topics in Microbiology and Immunology pp 199-218


Virion Assembly and Release

  • Brett D. LindenbachAffiliated withDepartment of Microbial Pathogenesis, Yale University School of Medicine Email author 

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Hepatitis C Virus (HCV) particles exhibit several unusual properties that are not found in other enveloped RNA viruses, most notably their low buoyant density and interaction with serum lipoproteins. With the advent of systems to grow HCV in cell culture, the molecular basis of HCV particle assembly and release can now be addressed. The process of virus assembly involves protein–protein interactions between viral structural and nonstructural proteins and the coordinated action of host factors. This chapter reviews our current understanding of these interactions and factors.