Coupled Plasma Filtration-adsorption

  • G. Berlot
  • A. Tomasini
  • A. Agbedjro
Part of the Annual Update in Intensive Care and Emergency Medicine book series (AUICEM, volume 2012)

Abstract

In the past 25 years, various techniques have been developed to remove endotoxin and/or the sepsis mediators produced and released during the interaction between the host and the infecting agent [1]. The rationale of this approach is based on the hypothesis that a reduction in the blood concentration of these compounds should determine a gradient favoring the elimination of these substances from the target cells [2]. All the techniques used so far are based on the passage of the blood through an extracorporeal circuit containing one or more filters that are supposed to exert their depurative effects either via the elimination of these substances or by sticking them on their surface. The first approach takes advantage of the membranes normally used during continuous renal replacement treatment (CRRT) for the treatment of acute kidney injury (AKI), the cut-off values of which are high enough to allow elimination of medium-high molecular weight (MW) mediators; to this aim, different blood flows (Qb) and ultrafiltrate flows (Qf) have been and are currently used. A second approach consists of use of plasma exchange, aimed at removing of one or more volumes of plasma, which is replaced with colloids, albumin or fresh frozen plasma (FFP) [3].

Keywords

Septic Shock Severe Sepsis Acute Kidney Injury Fresh Freeze Plasma Septic Shock Patient 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2012

Authors and Affiliations

  • G. Berlot
  • A. Tomasini
  • A. Agbedjro

There are no affiliations available

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