Intra-Operative Ex-Situ and In-Situ Optical Biopsy Using Light-CT

  • Martine Antoine
  • Brigitte Sigal
  • Fabrice Harms
  • Anne Latrive
  • Adriano Burcheri
  • Osnath Assayag
  • Bertrand de Poly
  • Sylvain Gigan
  • A. Claude Boccara
Conference paper
Part of the Advances in Intelligent and Soft Computing book series (AINSC, volume 120)

Abstract

The field of digital pathology is evolving very quickly: there is an increasing implication of laboratories and imaging companies in the biomedical field of histology. For our part we propose a digital imaging tool based on optical interferometry with short coherence length light sources (OCT). This instrument provides, without preparation or contrast agents , virtual sections of biological tissues with a field of view (1cm 2) and spatial resolution (approximately 1 micron in 3-D) suitable for histology. We show the relevance of this approach by comparing our images obtained in minutes during surgery with histological sections obtained after a few days. In these studies we worked on fixed tissue, fresh tissue in vivo or ex vivo. Finally, an endoscopic probe based on the same principle has been validated ex-vivo for use inside the bodies of patients.

Keywords

Optical Coherence Tomography Michelson Interferometer Optical Coherence Tomography System Multiphoton Microscopy Path Length Difference 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. [Fujimoto et al. 1995]
    Fujimoto, J.G., Brezinski, M.E., Tearney, G.J., Boppart, S.A., Bouma, B.E., Hee, M.R., Southern, J.F., Swanson, E.A.: Optical biopsy and imaging using optical coherence tomography. Nature Med. 1, 970–972 (1995)CrossRefGoogle Scholar

Copyright information

© Springer Berlin Heidelberg 2012

Authors and Affiliations

  • Martine Antoine
    • 1
  • Brigitte Sigal
    • 1
  • Fabrice Harms
    • 2
    • 3
  • Anne Latrive
    • 2
    • 3
  • Adriano Burcheri
    • 2
    • 3
  • Osnath Assayag
    • 2
    • 3
  • Bertrand de Poly
    • 2
    • 3
  • Sylvain Gigan
    • 2
    • 3
  • A. Claude Boccara
    • 2
    • 3
  1. 1.Hospital Tenon and Hospital CurieParisFrance
  2. 2.Institut Langevin ESPCI-ParistechParisFrance
  3. 3.LLTECH SASParisFrance

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