Gene Ontology Based Automated Annotation: Why It Isn’t Working
Genomics has seen a great deal of development since the milestone of the sequencing of the human genome by Craig Venter and Francis Collins in 2000. However, it is broadly accepted now that real challenges are lying ahead in actually understanding the meaning of these raw data. Traditionally this process of assigning meaning to biological crude data is being performed by domain specialists and has been known as annotation. As data chaos becomes larger due to rapid advances in sequencing technologies, the interest for automated annotation has equally increased. Current approaches are often based on the Gene Ontology (GO), but often fail to meet the requirements. Determining why and how they fail will prove crucial in finding methods that perform better, and ultimately might very well deliver the promising feat of turning the Human Genome data chaos into actual knowledge.
KeywordsGene Ontology Information System Automate Annotation Model Drive Architecture Token Function
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