Initial MPS Response of Adsorptively-Coated Fluorescent Iron Oxide Nanoparticles
The search for optimal nanoparticlesfor magnetic particle imaging (MPI) has been receiving much attention. Currently, Resovist® an iron oxide nanoparticle-based MR contrast agent is considered as the gold standard for MPS and MPI measurements. In this paper, we evaluate the initial MPS response of iron oxide-based nanoparticle systems with variation in core size and coating. In this context, we synthesized iron oxide nanoparticles with different core sizes (5 and 10 nm) by employing co-preciptiation method. Further, these iron cores were adsorptivelycoated with endogenous fluorophores (flavin analogues: FMN, FAD) to increase their stability and to enhance MR contrast. We have performed initial experiments on these particles in a magnetic particle spectrometer. Their spectrum of higher harmonics was obtained and found to fall off more rapidly than Resovist®. No difference in magnetic behavior was seen between particles with different coatings.
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- 1.Jayapaul, J., Hodenius, M., Arns, S., Lederle, W., Lammers, T., Comba, P., Kiessling, F., Gaetjens, J.: FMN-coated fluorescent iron oxide nanoparticles for RCP-mediated targeting and labeling of metabolically active cancer and endothelial cells. Biomaterials 32, 5863–5871 (2011)CrossRefGoogle Scholar
- 4.Jander, G., Jahr, K.: Massanalyse, 17th edn., pp. 219–221 (2009)Google Scholar