Initial MPS Response of Adsorptively-Coated Fluorescent Iron Oxide Nanoparticles

  • Jabadurai Jayapaul
  • Daniel Truhn
  • Fabian Kiessling
  • Kerstin Lüdtke-Buzug
  • Thorsten M. Buzug
Part of the Springer Proceedings in Physics book series (SPPHY, volume 140)

Abstract

The search for optimal nanoparticlesfor magnetic particle imaging (MPI) has been receiving much attention. Currently, Resovist® an iron oxide nanoparticle-based MR contrast agent is considered as the gold standard for MPS and MPI measurements. In this paper, we evaluate the initial MPS response of iron oxide-based nanoparticle systems with variation in core size and coating. In this context, we synthesized iron oxide nanoparticles with different core sizes (5 and 10 nm) by employing co-preciptiation method. Further, these iron cores were adsorptivelycoated with endogenous fluorophores (flavin analogues: FMN, FAD) to increase their stability and to enhance MR contrast. We have performed initial experiments on these particles in a magnetic particle spectrometer. Their spectrum of higher harmonics was obtained and found to fall off more rapidly than Resovist®. No difference in magnetic behavior was seen between particles with different coatings.

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Copyright information

© Springer-Verlag GmbH Berlin Heidelberg 2012

Authors and Affiliations

  • Jabadurai Jayapaul
    • 1
  • Daniel Truhn
    • 1
  • Fabian Kiessling
    • 1
  • Kerstin Lüdtke-Buzug
    • 2
  • Thorsten M. Buzug
    • 2
  1. 1.Institute of Experimental Molecular ImagingRWTH Aachen UniversityAachenGermany
  2. 2.Institute of Medical EngineeringUniversity of LuebeckLuebeckGermany

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