Ex Vivo Magnetic Sentinel Lymph Node Detection in Colorectal Cancer with a SPIO Tracer

  • Joost J. Pouw
  • Raluca M. Fratila
  • Aldrik H. Velders
  • Bennie ten Haken
  • Quentin A. Pankhurst
  • Joost M. Klaase
Part of the Springer Proceedings in Physics book series (SPPHY, volume 140)

Abstract

A new method for selecting sentinel lymph nodes (SNs) in colorectal cancer tissue was investigated in 12 patients. A tracer consisting of superparamagnetic ironoxide (SPIO) nanoparticles was injected in the resected tissue. A handheld magnetic probe was used to select SNs to which the SPIO was drained. Vibrating sample magnetometry was performed on the lymph nodes to quantify the amount of SPIO in the nodes. High-field MRI allowed to depict the distribution of SPIO in the node, and revealed small anatomical structures. One or more SPIO containing nodes were successfully selected with the magnetic probe in all 12 patients.

Keywords

Colorectal Cancer Sentinel Lymph Node Prussian Blue Sentinel Lymph Node Mapping Sentinel Lymph Node Detection 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    International Agency for Research on Cancer, GLOBOSCAN (2008), http://globoscan.iarc.fr
  2. 2.
    Tan, K.Y., et al.: Distribution of the first metastatic lymph node in colon cancer and its clinical significance. Colorectal Dis. 12(1), 44–47 (2010)CrossRefGoogle Scholar
  3. 3.
    Cahill, R.A., Leroy, J., Marescaux, J.: Could lymphatic mapping and sentinel node biopsy provide oncological providence for local resectional techniques for colon cancer? A review of the literature. BMC Surg. 8, 17 (2008)CrossRefGoogle Scholar
  4. 4.
    van der Zaag, E.S., et al.: Diagnosing occult tumour cells and their predictive value in sentinel nodes of histologically negative patients with colorectal cancer. Eur. J. Surg. Oncol. 36(4), 350–357 (2010)CrossRefGoogle Scholar
  5. 5.
    van Schaik, P.M., et al.: Ex vivo sentinel lymph node "mapping" in colorectal cancer. Eur. J. Surg. Oncol. 33(10), 1177–1182 (2007)CrossRefGoogle Scholar
  6. 6.
    Joshi, T., et al.: Magnetic nanoparticles for detecting sentinel lymph nodes. ESJO 33, 1135 (2007)Google Scholar
  7. 7.
    Park, J.S., et al.: Comparison of ex vivo and in vivo injection of blue dye in sentinel lymph node mapping for colorectal cancer. World J. Surg. 33(3), 539–546 (2009)CrossRefGoogle Scholar

Copyright information

© Springer-Verlag GmbH Berlin Heidelberg 2012

Authors and Affiliations

  • Joost J. Pouw
    • 1
  • Raluca M. Fratila
    • 1
  • Aldrik H. Velders
    • 2
  • Bennie ten Haken
    • 1
  • Quentin A. Pankhurst
    • 3
  • Joost M. Klaase
    • 4
  1. 1.MIRA Institute for Biomedical Technology & Technical Medicine, NeuroImaging GroupUniversity of TwenteEnschedeThe Netherlands
  2. 2.Biomedical Chemistry GroupUniversity of TwenteEnschedeThe Netherlands
  3. 3.Davy-Faraday Research LaboratoryThe Royal Institution of Great BritainLondonUK
  4. 4.Department of SurgeryMedisch Spectrum TwenteEnschedeThe Netherlands

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