Superparamagnetic Iron Oxide Nanoparticles: Evaluation of Stability of SPIONs in Different Milieu for Magnetic Particle Imaging

  • Kerstin Lüdtke-BuzugEmail author
  • Céline Borchers
Part of the Springer Proceedings in Physics book series (SPPHY, volume 140)


Today, a variety of different nanoparticles are used in various applications. In particular, super-paramagnetic iron oxide nanoparticles (or SPIONs) are used in vitro for cell separation and in vivo for hyperthermia or as contrast agent for magnetic resonance imaging (MRI). However, in Magnetic Particle Imaging (MPI), SPIONs play a fundamental role as tracer material. In addition to the overall size of the particles and the particle coating, which are important for medical applications, it is the magnetic core diameter that is relevant for the performance in MPI applications. In general, for in vivo applications, the stability of the particles is of key importance. Therefore, in this paper, the stability of the SPIONs have been analyzed in different particle suspension media.


Magnetic Nanoparticles Hydrodynamic Diameter Magnetic Core Superparamagnetic Iron Oxide Suspension Medium 
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© Springer-Verlag GmbH Berlin Heidelberg 2012

Authors and Affiliations

  1. 1.Institute of Medical EngineeringUniversity of LuebeckLübeckGermany

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