Introduction

  • Dan Lin
  • Willem Talloen
  • Luc Bijnens
  • Hinrich W. H. Göhlmann
  • Dhammika Amaratunga
  • Roel Straetemans
Chapter
Part of the Use R! book series (USE R)

Abstract

The development of new and innovative treatments for unmet medical (Barlow et al. 1972) needs is the major challenge in biomedical research. Unfortunately, for the past decade, there has been a steady decline in the number of new therapies reaching the market, despite of the increased investments in pharmaceutical R&D (FDA 2004). One of the most critical steps in a drug discovery program is target identification and validation (Sams-Dodd 2005).

Keywords

False Positive Finding Inference Step Drug Discovery Program False Positive Gene Specific Biological Pathway 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2012

Authors and Affiliations

  • Dan Lin
    • 1
  • Willem Talloen
    • 2
  • Luc Bijnens
    • 2
  • Hinrich W. H. Göhlmann
    • 2
  • Dhammika Amaratunga
    • 3
  • Roel Straetemans
    • 4
  1. 1.Veterinary Medicine Research and DevelopmentPfizer Animal HealthZaventemBelgium
  2. 2.Janssen Pharmaceutical Companies of Johnson & JohnsonBeerseBelgium
  3. 3.Biostatistics and ProgrammingJanssen Pharmaceutical Companies of Johnson & JohnsonRaritanUSA
  4. 4.Ablynx NVZwijnaardeBelgium

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