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3D Simulation of an invitro Epithelial to Mesenchymal Transition

  • R. Summers
  • T. Abdulla
  • R. A. Imms
  • J. M. Schleich
Part of the IFMBE Proceedings book series (IFMBE, volume 37)

Abstract

A 3D simulation of in vitro epithelial to mesenchymal transition (EMT) is presented. The simulation uses Compucell3D to realize a cellular Potts model of this process. The purpose of the model is to test the hypothesis that EMT can be achieved through a combination of a) the loss of endocardial cohesion; and b) a gain of endocardial to extracellular matrix adhesion. The results of the simulation demonstrate confirmation of the hypothesis. A mechanism by which EMT could be regulated by mitosis is demonstrated. Further, the implication of the study to heart development is explored.

Keywords

Cellular Potts GGH Multiscale Heart 

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Copyright information

© Springer-Verlag Berlin Heidelberg 2011

Authors and Affiliations

  • R. Summers
    • 1
  • T. Abdulla
    • 1
  • R. A. Imms
    • 1
  • J. M. Schleich
    • 2
  1. 1.Research School of Systems EngineeringLoughborough UniversityLoughboroughUK
  2. 2.LTSIUniversité de Rennes 1RennesFrance

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