A Practical Algorithm for Ancestral Rearrangement Reconstruction

  • Jakub Kováč
  • Broňa Brejová
  • Tomáš Vinař
Part of the Lecture Notes in Computer Science book series (LNCS, volume 6833)

Abstract

Genome rearrangements are a valuable source of information about early evolution, as well as an important factor in speciation processes. Reconstruction of ancestral gene orders on a phylogeny is thus one of the crucial tools contributing to understanding of evolution of genome organization. For most models of evolution, this problem is NP-hard.

We have developed a universal method for reconstruction of ancestral gene orders by parsimony (PIVO) using an iterative local optimization procedure. Our method can be applied to different rearrangement models. Combined with a sufficently rich model, such as the double cut and join (DCJ), it can support a mixture of different chromosomal architectures in the same tree. We show that PIVO can outperform previously used steinerization framework and achieves better results on real data than previously published methods.

Datasets, reconstructed histories, and the software can be downloaded at http://compbio.fmph.uniba.sk/pivo/

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Copyright information

© Springer-Verlag Berlin Heidelberg 2011

Authors and Affiliations

  • Jakub Kováč
    • 1
  • Broňa Brejová
    • 1
  • Tomáš Vinař
    • 2
  1. 1.Department of Computer Science, Faculty of Mathematics, Physics, and InformaticsComenius UniversityBratislavaSlovakia
  2. 2.Department of Applied Informatics, Faculty of Mathematics, Physics, and InformaticsComenius UniversityBratislavaSlovakia

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