Morphogenesis of Cryptococcus neoformans

  • Elizabeth R. Ballou
  • J. Andrew AlspaughEmail author
  • Connie B. Nichols
Part of the Topics in Current Genetics book series (TCG, volume 22)


Cryptococcus neoformans was first recognized as a human pathogen over 100 years ago when it was independently isolated from a patient with a tibial infection and from environmental sources (peach juice). This basidiomycete has subsequently been isolated from most regions of the world, causing a significant number of lethal infections each year, especially in AIDS patients. Originally described as a yeast-like fungus causing human and animal infections, C. neoformans is now known to undergo morphological transitions that are important for its survival and dissemination. Some of the signaling pathways that control yeast and hyphal morphogenesis in this organism are also central regulators of its pathogenesis.


Cell Fusion Spindle Pole Body Pheromone Receptor Clamp Cell Subapical Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer-Verlag Berlin Heidelberg 2012

Authors and Affiliations

  • Elizabeth R. Ballou
    • 1
  • J. Andrew Alspaugh
    • 1
    Email author
  • Connie B. Nichols
    • 1
  1. 1.Departments of Medicine and Molecular Genetics/MicrobiologyDuke University School of MedicineSouth DurhamUSA

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