MicroRNA or Not MicroRNA?

  • David Langenberger
  • Sebastian Bartschat
  • Jana Hertel
  • Steve Hoffmann
  • Hakim Tafer
  • Peter F. Stadler
Part of the Lecture Notes in Computer Science book series (LNCS, volume 6832)

Abstract

The avalanche of next generation sequencing data has led to a rapid increase of annotated microRNAs in the last few years. Many of them are specific to individual species or rather narrow clades. A closer inspection of the current version of miRBase shows that dozens of entries conflict with other ncRNAs, in particular snoRNAs. With few exceptions, these cases show little similarities to canonical microRNAs, however, and thus they should be considered as mis-annotations.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2011

Authors and Affiliations

  • David Langenberger
    • 1
    • 2
    • 3
  • Sebastian Bartschat
    • 1
  • Jana Hertel
    • 1
    • 2
  • Steve Hoffmann
    • 3
    • 2
  • Hakim Tafer
    • 1
    • 2
  • Peter F. Stadler
    • 1
    • 2
    • 3
    • 4
    • 5
    • 6
    • 7
    • 8
  1. 1.Bioinformatics Group, Department of Computer ScienceUK
  2. 2.Interdisciplinary Center for BioinformaticsUniversity of LeipzigLeipzigGermany
  3. 3.LIFE – Leipzig Research Center for Civilization DiseasesUniversity of LeipzigGermany
  4. 4.Max Planck Institute for Mathematics in the SciencesLeipzigGermany
  5. 5.Fraunhofer Institut für Zelltherapie und ImmunologieLeipzigGermany
  6. 6.Department of Theoretical ChemistryUniversity of ViennaWienAustria
  7. 7.Center for non-coding RNA in Technology and HealthUniversity of CopenhagenFrederiksberg CDenmark
  8. 8.Santa Fe InstituteSanta FeUSA

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