Modelling Containment Mechanisms in the Immune System for Applications in Engineering

(Extended Abstract)
  • Amelia Ritahani Ismail
  • Jon Timmis
Part of the Lecture Notes in Computer Science book series (LNCS, volume 6825)

Granuloma Formation

Granuloma formation is a complex process involving a variety of mechanisms acting in concert to afford an inflammatory lesion that is able to contain and destroy intracellular pathogens. While it is crucial for host defence, inappropriate granulomatous inflammation can also damage the host. Granuloma formation is comprised of four main steps : (1) the triggering of T cells by antigen presenting cells, represented by alveolar macrophages and dendritic cells; (2) the release of cytokines and chemokines by macrophages, activated lymphocytes and dendritic cells. Cytokines and chemokines attract and retain in the lung the immuno-inflammatory cell populations in the lung, inducing their survival and proliferation at the site of ongoing inflammation, favouring (3) the stable and dynamic accumulation of immunocompetent cells and the formation of the organised structure of the granuloma. In granulomatous diseases, the last phase (4) of granuloma formation generally ends in fibrosis. Granuloma formation is initiated when an infectious diseases enters the host. Macrophages will ‘eat′ or engulf bacteria to prevent it from spreading. However, bacteria will infect macrophages and duplicate. Despite the fact that macrophages are able to stop the infection, bacteria will use macrophages as a ‘taxi′ to spread the disease within the host leading to cell lysis or the breaking down of the structure of the cell. Infected macrophages then will emit a signal which indicates that they have been infected and this signal will lead other macrophages to move to the site of infection, to form a ring around the infected macrophages thus isolating the infected cells from the uninfected cells. This will finally lead to the formation of a granuloma that represents a chronic inflammatory response initiated by various infectious and non-infectious agents.


Granuloma Formation Intracellular Bacterium Infected Macrophage Will Emit Extracellular Bacterium 
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Copyright information

© Springer-Verlag Berlin Heidelberg 2011

Authors and Affiliations

  • Amelia Ritahani Ismail
    • 1
    • 2
    • 3
  • Jon Timmis
    • 1
    • 2
    • 3
  1. 1.Department of Computer ScienceUniversity of YorkHeslingtonUK
  2. 2.Department of ElectronicsUniversity of YorkHeslingtonUK
  3. 3.Kulliyyah of ICTIIUMKuala LumpurMalaysia

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